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Tbio
GPSM3
G-protein-signaling modulator 3

Protein Summary
Description
Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375040
  • ENSP00000364180
  • ENSG00000213654
  • ENST00000375043
  • ENSP00000364183
  • ENST00000383265
  • ENSP00000372752
  • ENSG00000206314
  • ENST00000383269
  • ENSP00000372756
  • ENST00000414839
  • ENSP00000405026
  • ENSG00000236697
  • ENST00000420041
  • ENSP00000413975
  • ENSG00000233490
  • ENST00000424520
  • ENSP00000413430
  • ENSG00000237052
  • ENST00000429209
  • ENSP00000392487
  • ENSG00000234243
  • ENST00000432871
  • ENSP00000414939
  • ENSG00000234508
  • ENST00000441705
  • ENSP00000396786
  • ENST00000445326
  • ENSP00000407538
  • ENST00000448684
  • ENSP00000403132
  • ENST00000453667
  • ENSP00000414024
  • ENST00000457070
  • ENSP00000410087

Symbol
  • AGS4
  • C6orf9
  • G18
  • G18
  • NG1
  • AGS4
  • G18.2
  • C6orf9
  • G18.1a
  • G18.1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.69
gene perturbation
0.6
tissue
0.59
phenotype
0.58
co-expressed gene
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.7   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.7   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (272)
MAU2
Tdark
Novelty:  0.00594861
p_int:  0.999999891
p_ni:  1.09e-7
Data Source:  BioPlex
PHF1
Tbio
Family:  Epigenetic
Novelty:  0.00430297
p_int:  0.999999322
p_ni:  6.55e-7
p_wrong:  2.4e-8
Data Source:  BioPlex
NIPBL
Tbio
Novelty:  0.00462654
p_int:  0.999895764
p_ni:  0.000003802
p_wrong:  0.000100434
Data Source:  BioPlex
MARK1
Tchem
Family:  Kinase
Novelty:  0.02342173
p_int:  0.999852211
p_ni:  0.000147657
p_wrong:  1.32e-7
Data Source:  BioPlex
PM20D2
Tdark
Family:  Enzyme
Novelty:  0.63491472
p_int:  0.99984709
p_ni:  0.00015291
Data Source:  BioPlex
MARK3
Tchem
Family:  Kinase
Novelty:  0.01304552
p_int:  0.999781015
p_ni:  0.000218956
p_wrong:  3e-8
Data Source:  BioPlex
TRMU
Tbio
Family:  Enzyme
Novelty:  0.01615197
p_int:  0.999775412
p_ni:  0.000214152
p_wrong:  0.000010436
Data Source:  BioPlex
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.997801624
p_ni:  0.002198376
Data Source:  BioPlex
GNAT2
Tbio
Novelty:  0.01683655
p_int:  0.997543085
p_ni:  0.00000524
p_wrong:  0.002451675
Data Source:  BioPlex
FAM114A2
Tdark
Novelty:  0.40545319
p_int:  0.997424875
p_ni:  0.002450575
p_wrong:  0.00012455
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (539)
Items per page:
1 – 5 of 539
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
Items per page:
1 – 5 of 539
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein signaling modulator 3
VGNC:52011
462586
Macaque
G protein signaling modulator 3
717356
Mouse
MGI:2146785
106512
Rat
RGD:1303014
406163
Dog
G protein signaling modulator 3
VGNC:41459
607687
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein signaling modulator 3
Macaque
G protein signaling modulator 3
Mouse
Rat
Dog
G protein signaling modulator 3
Publication Statistics
PubMed Score 67.70
PubMed score by year
PubTator Score 22.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title