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Tchem
GPRC6A
G-protein coupled receptor family C group 6 member A

Protein Summary
Description
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids. Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310357
  • ENSP00000309493
  • ENSG00000173612
  • ENST00000368549
  • ENSP00000357537
  • ENST00000530250
  • ENSP00000433465

Symbol
  • GPCR
  • bA86F4.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.73
tissue
0.51
ligand (chemical)
0.49
metabolite
0.45


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.61   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.61   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (203)
FFAR2
Tchem
Family:  GPCR
Novelty:  0.00361123
Score:  0.97
Data Source:  STRINGDB
LPAR5
Tchem
Family:  GPCR
Novelty:  0.01883439
Score:  0.958
Data Source:  STRINGDB
FFAR1
Tchem
Family:  GPCR
Novelty:  0.00271782
Score:  0.957
Data Source:  STRINGDB
FFAR3
Tchem
Family:  GPCR
Novelty:  0.00746169
Score:  0.956
Data Source:  STRINGDB
FFAR4
Tchem
Family:  GPCR
Novelty:  0.00439747
Score:  0.948
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.944
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.94
Data Source:  STRINGDB
CCK
Tbio
Novelty:  0.00012268
Score:  0.93
Data Source:  STRINGDB
GAST
Tbio
Novelty:  0.00011795
Score:  0.93
Data Source:  STRINGDB
NPSR1
Tchem
Family:  GPCR
Novelty:  0.00562139
Score:  0.928
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
2
0
1.2
79.3
glucose measurement
1
1
1
60.2
apolipoprotein A 1 measurement
1
1
1
50.6
1
1
0
1.1
39.6
C-reactive protein measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
79.3
glucose measurement
1
60.2
apolipoprotein A 1 measurement
1
50.6
0
1.1
39.6
C-reactive protein measurement
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor class C group 6 member A
VGNC:8165
472105
Macaque
G protein-coupled receptor class C group 6 member A
715520
Mouse
MGI:2429498
210198
Rat
RGD:735077
294394
Dog
G protein-coupled receptor class C group 6 member A
VGNC:41452
484095
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor class C group 6 member A
Macaque
G protein-coupled receptor class C group 6 member A
Mouse
Rat
Dog
G protein-coupled receptor class C group 6 member A
Publication Statistics
PubMed Score 67.61
PubMed score by year
PubTator Score 36.02
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title