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Tbio
GPR89A
Golgi pH regulator A

Protein Summary
Description
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313835
  • ENSP00000319673
  • ENSG00000117262
  • ENST00000460277
  • ENSP00000436705
  • ENST00000462900
  • ENSP00000432248
  • ENST00000528944
  • ENSP00000434108
  • ENST00000534502
  • ENSP00000434495

Symbol
  • GPHRA
  • GPR89
  • SH120
  • GPHR
  • GPR89
  • SH120
  • GPR89C
  • UNQ192
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
cellular component
0.66
tissue sample
0.56
tissue
0.55
cell line
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.8   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.8   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.999488525
p_ni:  0.000511475
Data Source:  BioPlex
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.999144692
p_ni:  0.000855308
Data Source:  BioPlex
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.996138312
p_ni:  0.003861688
Data Source:  BioPlex
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.994938321
p_ni:  0.005061679
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.994056061
p_ni:  0.005943939
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.993633149
p_ni:  0.006366851
Data Source:  BioPlex
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.990900999
p_ni:  0.009099001
Data Source:  BioPlex
SLC7A14
Tbio
Family:  Transporter
Novelty:  0.1613451
p_int:  0.987991316
p_ni:  0.01200868
p_wrong:  4e-9
Data Source:  BioPlex
TACR1
Tclin
Family:  GPCR
Novelty:  0.00062762
p_int:  0.987203043
p_ni:  0.012796953
p_wrong:  4e-9
Data Source:  BioPlex
TMEM63C
Tdark
Family:  IC
Novelty:  0.02849254
p_int:  0.974687419
p_ni:  0.025300277
p_wrong:  0.000012304
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
8
7
11
3.3
99.1
uric acid measurement
4
4
7
93.1
diastolic blood pressure
1
1
1
39.6
contrast sensitivity measurement
1
1
0
5.7
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
11
3.3
99.1
uric acid measurement
7
93.1
diastolic blood pressure
1
39.6
contrast sensitivity measurement
0
5.7
26.6
Find similar targets by:
IDG Resources
Cell
image for
Details:
  • Species:  Homo sapiens
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 89A
457978
Mouse
MGI:1914799
67549
Rat
RGD:1304837
362003
Dog
G protein-coupled receptor 89A
483157
Cow
G protein-coupled receptor 89A
767859
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 89A
Mouse
Rat
Dog
G protein-coupled receptor 89A
Cow
G protein-coupled receptor 89A
Publication Statistics
PubMed Score 16.80
PubMed score by year
PubTator Score 0.17
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title