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Tchem
GPR83
Probable G-protein coupled receptor 83

Protein Summary
Description
Orphan receptor. Could be a neuropeptide Y receptor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243673
  • ENSP00000243673
  • ENSG00000123901

Symbol
  • GPR72
  • KIAA1540
  • GIR
  • GPR72
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.7
histone modification site profile
0.6
microRNA
0.6
PubMedID
0.59
gene perturbation
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.02   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 363   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.02   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 363   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (154)
GPR150
Tdark
Family:  GPCR
Novelty:  0.91287003
Score:  0.977
Data Source:  STRINGDB
ADCY3
Tbio
Family:  Enzyme
Novelty:  0.00260265
Score:  0.971
Data Source:  STRINGDB
ADCY8
Tchem
Family:  Enzyme
Novelty:  0.00510386
Score:  0.957
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.932
Data Source:  STRINGDB
GCGR
Tclin
Family:  GPCR
Novelty:  0.00392059
Score:  0.929
Data Source:  STRINGDB
GPR39
Tchem
Family:  GPCR
Novelty:  0.01244607
Score:  0.928
Data Source:  STRINGDB
GLP1R
Tclin
Family:  GPCR
Novelty:  0.0006899
Score:  0.925
Data Source:  STRINGDB
GPR45
Tbio
Family:  GPCR
Novelty:  0.08366919
Score:  0.925
Data Source:  STRINGDB
CRHR1
Tclin
Family:  GPCR
Novelty:  0.00101773
Score:  0.922
Data Source:  STRINGDB
VIP
Tbio
Novelty:  0.00024946
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
1
4
83.5
1
1
1
0.9
sleep apnea measurement
1
1
1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
83.5
1
0.9
sleep apnea measurement
1
0.9
Find similar targets by:
IDG Resources
Genetic Construct
GPR83-Tango
image for GPR83-Tango
Details:
  • Vector:  addgene66376
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR83-Tango
Order Genetic Construct from:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 83
VGNC:6488
466752
Macaque
G protein-coupled receptor 83
697439
Mouse
MGI:95712
14608
Rat
RGD:619891
140595
Dog
G protein-coupled receptor 83
VGNC:41445
403699
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 83
Macaque
G protein-coupled receptor 83
Mouse
Rat
Dog
G protein-coupled receptor 83
Publication Statistics
PubMed Score 29.02
PubMed score by year
PubTator Score 25.43
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title