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Tbio
GPR75
Probable G-protein coupled receptor 75

Protein Summary
Description
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394705
  • ENSP00000378195
  • ENSG00000119737

Symbol
  • GPRchr2
  • WI31133
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
cell type or tissue
0.52
histone modification site profile
0.52
cell line
0.46
molecular function
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.07   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.07   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
GPR45
Tbio
Family:  GPCR
Novelty:  0.08366919
Score:  0.766
Data Source:  STRINGDB
GPR83
Tchem
Family:  GPCR
Novelty:  0.03554942
Score:  0.745
Data Source:  STRINGDB
GPR63
Tchem
Family:  GPCR
Novelty:  0.28759528
Score:  0.743
Data Source:  STRINGDB
F10
Tclin
Family:  Enzyme
Novelty:  0.00063008
Score:  0.71
Data Source:  STRINGDB
GPR88
Tchem
Family:  GPCR
Novelty:  0.02963528
Score:  0.643
Data Source:  STRINGDB
GPR150
Tdark
Family:  GPCR
Novelty:  0.91287003
Score:  0.643
Data Source:  STRINGDB
ATXN7L1
Tdark
Novelty:  0.43694835
Score:  0.566
Data Source:  STRINGDB
GPR52
Tchem
Family:  GPCR
Novelty:  0.07988639
Score:  0.527
Data Source:  STRINGDB
GPR141
Tdark
Family:  GPCR
Novelty:  0.30711523
Score:  0.48
Data Source:  STRINGDB
GPR162
Tbio
Family:  GPCR
Novelty:  0.14938549
Score:  0.476
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
2
2
87.8
reticulocyte measurement
2
2
2
79.8
hemoglobin measurement
2
2
2
79.2
lymphocyte count
2
2
2
70.4
reticulocyte count
2
1
2
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
87.8
reticulocyte measurement
2
79.8
hemoglobin measurement
2
79.2
lymphocyte count
2
70.4
reticulocyte count
2
70.2
Find similar targets by:
IDG Resources
Genetic Construct
GPR75-Tango
image for GPR75-Tango
Details:
  • Vector:  addgene66372
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR75-Tango
Order Genetic Construct from:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 75
VGNC:262
470376
Macaque
G protein-coupled receptor 75
100426871
Mouse
MGI:2441843
237716
Rat
RGD:1566385
498434
Horse
G protein-coupled receptor 75
VGNC:18547
100066961
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 75
Macaque
G protein-coupled receptor 75
Mouse
Rat
Horse
G protein-coupled receptor 75
Publication Statistics
PubMed Score 10.07
PubMed score by year
PubTator Score 3.56
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title