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Tchem
GPR63
Probable G-protein coupled receptor 63

Protein Summary
Description
Orphan receptor. May play a role in brain function. This gene encodes a G protein-coupled receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229955
  • ENSP00000229955
  • ENSG00000112218

Symbol
  • PSP24B
  • PSP24B
  • PSP24(beta)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.73
tissue sample
0.7
chemical
0.41
virus perturbation
0.41
gene perturbation
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.63   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.63   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (34)
GPR75
Tbio
Family:  GPCR
Novelty:  0.11693296
Score:  0.743
Data Source:  STRINGDB
KLHL32
Tdark
Novelty:  0.6299831
Score:  0.63
Data Source:  STRINGDB
FUT6
Tchem
Family:  Enzyme
Novelty:  0.0123682
Score:  0.613
Data Source:  STRINGDB
GPR6
Tchem
Family:  GPCR
Novelty:  0.05964344
Score:  0.613
Data Source:  STRINGDB
GPR132
Tchem
Family:  GPCR
Novelty:  0.00453902
Score:  0.602
Data Source:  STRINGDB
GPR3
Tchem
Family:  GPCR
Novelty:  0.02331106
Score:  0.6
Data Source:  STRINGDB
GPR18
Tchem
Family:  GPCR
Novelty:  0.0178347
Score:  0.575
Data Source:  STRINGDB
GPR27
Tbio
Family:  GPCR
Novelty:  0.164488
Score:  0.566
Data Source:  STRINGDB
ZNF222
Tdark
Family:  TF
Novelty:  1.50562038
Score:  0.563
Data Source:  STRINGDB
TEX36
Tdark
Novelty:  2.34991593
Score:  0.548
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
8
IDG Resources
Genetic Construct
GPR63-Tango
image for GPR63-Tango
Details:
  • Vector:  addgene66368
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR63-Tango
Order Genetic Construct from:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 63
VGNC:11088
462890
Mouse
MGI:2135884
81006
Rat
RGD:1306460
297952
Dog
G protein-coupled receptor 63
VGNC:41441
100685057
Horse
G protein-coupled receptor 63
VGNC:18545
100071441
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 63
Mouse
Rat
Dog
G protein-coupled receptor 63
Horse
G protein-coupled receptor 63
Publication Statistics
PubMed Score 3.63
PubMed score by year
PubTator Score 2.50
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title