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Tchem
GPR52
G-protein coupled receptor 52

Protein Summary
Description
Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM, Jul 2002]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367685
  • ENSP00000356658
  • ENSG00000203737
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.49
cell line
0.41
tissue sample
0.37
transcription factor
0.35
interacting protein
0.31


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.7   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.7   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (27)
CHEMBL3299119
Rendered image for CHEMBL3299119
CHEMBL4226295
Rendered image for CHEMBL4226295
CHEMBL4229128
Rendered image for CHEMBL4229128
CHEMBL4059658
Rendered image for CHEMBL4059658
CHEMBL4229063
Rendered image for CHEMBL4229063
CHEMBL4226695
Rendered image for CHEMBL4226695
CHEMBL4087237
Rendered image for CHEMBL4087237
CHEMBL4075971
Rendered image for CHEMBL4075971
CHEMBL3298233
Rendered image for CHEMBL3298233
Protein-Protein Interactions (51)
SYNGR2
Tbio
Novelty:  0.1089664
p_int:  0.975167835
p_ni:  0.024832164
p_wrong:  1e-9
Data Source:  BioPlex
FITM2
Tdark
Novelty:  0.01882177
p_int:  0.971651013
p_ni:  0.02833541
p_wrong:  0.000013578
Data Source:  BioPlex
ERMP1
Tbio
Family:  Enzyme
Novelty:  0.16736317
p_int:  0.912522251
p_ni:  0.087477749
Score:  0.186
Data Source:  BioPlex,STRINGDB
ALG8
Tbio
Family:  Enzyme
Novelty:  0.03721075
p_int:  0.897874703
p_ni:  0.102124923
p_wrong:  3.74e-7
Data Source:  BioPlex
LMBR1
Tbio
Novelty:  0.00591824
p_int:  0.885719272
p_ni:  0.114280487
p_wrong:  2.41e-7
Data Source:  BioPlex
YIPF4
Tdark
Novelty:  0.17862058
p_int:  0.885541085
p_ni:  0.112835585
p_wrong:  0.00162333
Data Source:  BioPlex
EBP
Tchem
Family:  Enzyme
Novelty:  0.00610658
p_int:  0.88177152
p_ni:  0.115418524
p_wrong:  0.002809956
Data Source:  BioPlex
TMEM56
Tdark
Novelty:  0.75633366
p_int:  0.87329646
p_ni:  0.02568354
p_wrong:  0.101020001
Score:  0.173
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.845258389
p_ni:  0.154741611
Data Source:  BioPlex
AGPAT3
Tbio
Family:  Enzyme
Novelty:  0.06139822
p_int:  0.841679036
p_ni:  0.158320964
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
70.4
neutrophil count
2
2
2
70.4
chronotype measurement
2
1
2
69.8
mathematical ability
1
1
1
58.4
neuroticism measurement
2
2
0
6
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
70.4
neutrophil count
2
70.4
chronotype measurement
2
69.8
mathematical ability
1
58.4
neuroticism measurement
0
6
47.5
Find similar targets by:
IDG Resources
Genetic Construct
GPR52-Tango
image for GPR52-Tango
Details:
  • Vector:  addgene66362
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR52-Tango
Order Genetic Construct from:
Publication Statistics
PubMed Score 18.70
PubMed score by year
PubTator Score 2.89
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title