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Tbio
GPR45
Probable G-protein coupled receptor 45

Protein Summary
Description
Orphan receptor. May play a role in brain function. This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258456
  • ENSP00000258456
  • ENSG00000135973

Symbol
  • PSP24
  • PSP24A
  • PSP24(ALPHA)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.65
cell type or tissue
0.63
tissue
0.56
virus perturbation
0.45
cell line
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.04   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.04   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (142)
GNG10
Tdark
Novelty:  0.37659459
Score:  0.943
Data Source:  STRINGDB
GPR27
Tbio
Family:  GPCR
Novelty:  0.164488
Score:  0.943
Data Source:  STRINGDB
GIPR
Tchem
Family:  GPCR
Novelty:  0.00961809
Score:  0.942
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.938
Data Source:  STRINGDB
GPR150
Tdark
Family:  GPCR
Novelty:  0.91287003
Score:  0.938
Data Source:  STRINGDB
GPR20
Tdark
Family:  GPCR
Novelty:  0.34435286
Score:  0.931
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.93
Data Source:  STRINGDB
GPR176
Tdark
Family:  GPCR
Novelty:  0.28180289
Score:  0.929
Data Source:  STRINGDB
ADCYAP1R1
Tchem
Family:  GPCR
Novelty:  0.00786286
Score:  0.927
Data Source:  STRINGDB
GPR83
Tchem
Family:  GPCR
Novelty:  0.03554942
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
1
2
59.6
age at menarche
2
2
2
57.7
body mass index
1
1
1
40.7
1
1
1
27.3
intelligence
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
59.6
age at menarche
2
57.7
body mass index
1
40.7
1
27.3
intelligence
1
27.3
Find similar targets by:
IDG Resources
Genetic Construct
GPR45-Tango
image for GPR45-Tango
Details:
  • Vector:  addgene66360
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR45-Tango
Order Genetic Construct from:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor 45
718033
Mouse
MGI:2135882
93690
Rat
RGD:1306253
301372
Dog
G protein-coupled receptor 45
VGNC:41436
481321
Horse
G protein-coupled receptor 45
VGNC:18543
100050078
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor 45
Mouse
Rat
Dog
G protein-coupled receptor 45
Horse
G protein-coupled receptor 45
Publication Statistics
PubMed Score 11.04
PubMed score by year
PubTator Score 6.02
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title