Tbio GPR37L1 G-protein coupled receptor 37-like 1

Protein Summary

Description

G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).

Uniprot Accession IDs

• O60883
• B2R7M9
• Q5SXP7
• Q86VP7

Gene Name

• GPR37L1

Ensembl ID

• ENST00000367282
• ENSP00000356251
• ENSG00000170075

Symbol

• ETBRLP2
• ETBRLP2
• ETBR-LP-2
• ET(B)R-LP-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.64
gene perturbation	0.63
cell line	0.59
tissue	0.5
pathway	0.47

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Endothelin Receptor / Prosaposin Receptor Gpr37l1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.03   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 272   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.03   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0