GPR34
Probable G-protein coupled receptor 34
Protein Summary
Orphan receptor. G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]
- ENST00000378138
- ENSP00000367378
- ENSG00000171659
- ENST00000378142
- ENSP00000367384
- ENST00000649219
- ENSP00000498130
- LYPSR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.67 | ||
tissue sample | 0.56 | ||
cell type or tissue | 0.54 | ||
pathway | 0.52 | ||
phenotype | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.7 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 275 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.7 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 275 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (6)
Protein-Protein Interactions (28)
Nearest Tclin Targets
Pathways (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GPCRs, Class A Rhodopsin-like | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (2)
Components (1)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Reagents (1)
Genetic Construct
GPR34-Tango
Details:
- Vector: addgene66353
- Vector backbone: pcDNA3.1(+)
- Promoter: CMV
- Tag: FLAG
Data:
- GPR34-Tango
Order Genetic Construct from:
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor 34 | VGNC:1377 | 473572 | |||||
Macaque | G protein-coupled receptor 34 | 700887 | ||||||
Mouse | MGI:1346334 | 23890 | ||||||
Rat | RGD:1563681 | 554353 | ||||||
Dog | G protein-coupled receptor 34 | VGNC:41431 | 100683845 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor 34 | |||||
Macaque | G protein-coupled receptor 34 | |||||
Mouse | ||||||
Rat | ||||||
Dog | G protein-coupled receptor 34 | |||||
Publication Statistics
PubMed Score 31.70
PubMed score by year
PubTator Score 17.39
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (17)
GeneRif Annotations (7)
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PMID | Year | Title |
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