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Tchem
GPR3
G-protein coupled receptor 3

Protein Summary
Description
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity). This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374024
  • ENSP00000363136
  • ENSG00000181773

Symbol
  • ACCA
  • ACCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
transcription factor
0.79
small molecule perturbation
0.61
gene perturbation
0.6
transcription factor binding site profile
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.78   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.78   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (48)
DMWD
Tbio
Novelty:  0.04096001
p_int:  0.950358651
p_ni:  0.049641349
Score:  0.515
Data Source:  BioPlex,STRINGDB
APOD
Tbio
Novelty:  0.0031899
p_int:  0.884171441
p_ni:  0.115828557
p_wrong:  1e-9
Score:  0.237
Data Source:  BioPlex,STRINGDB
APP
Tchem
Novelty:  0.00008964
Score:  0.723
Data Source:  STRINGDB
ARRB1
Tbio
Novelty:  0.00262758
Score:  0.696
Data Source:  STRINGDB
CCR10
Tchem
Family:  GPCR
Novelty:  0.014331
Score:  0.654
Data Source:  STRINGDB
NPPC
Tbio
Novelty:  0.00114199
Score:  0.648
Data Source:  STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
Score:  0.643
Data Source:  STRINGDB
GPR1
Tchem
Family:  GPCR
Novelty:  0.01313419
Score:  0.635
Data Source:  STRINGDB
GPR63
Tchem
Family:  GPCR
Novelty:  0.28759528
Score:  0.6
Data Source:  STRINGDB
GPR4
Tchem
Family:  GPCR
Novelty:  0.01592989
Score:  0.591
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
Genetic Construct
GPR3-Tango
image for GPR3-Tango
Details:
  • Vector:  addgene66350
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR3-Tango
Order Genetic Construct from:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor 3
716033
Mouse
MGI:101908
14748
Rat
RGD:628686
266769
Dog
G protein-coupled receptor 3
VGNC:41429
487344
Horse
G protein-coupled receptor 3
VGNC:18538
100070910
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor 3
Mouse
Rat
Dog
G protein-coupled receptor 3
Horse
G protein-coupled receptor 3
Publication Statistics
PubMed Score 53.78
PubMed score by year
PubTator Score 82.54
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title