Tbio GPR26 G-protein coupled receptor 26

Protein Summary

Description

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q8NDV2
• Q2M2E2

Gene Name

• GPR26

Ensembl ID

• ENST00000284674
• ENSP00000284674
• ENSG00000154478

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.83
gene perturbation	0.59
cell line	0.43
phenotype	0.39
transcription factor	0.37

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / G-protein Coupled Receptor 26

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / G-protein Coupled Receptor 26

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.63   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 151   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.63   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0