Tdark GPR20 G-protein coupled receptor 20

Protein Summary

Description

Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.

Uniprot Accession IDs

• Q99678
• Q17R96

Gene Name

• GPR20

Ensembl ID

• ENST00000377741
• ENSP00000366970
• ENSG00000204882
• ENST00000613887
• ENSP00000479665
• ENSG00000275181

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.77
cell type or tissue	0.59
PubMedID	0.58
cell line	0.47
transcription factor	0.44

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Purinoceptor / G-protein Coupled Receptor 20

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.1   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 244   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.1   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0