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Tdark
GPR20
G-protein coupled receptor 20

Protein Summary
Description
Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377741
  • ENSP00000366970
  • ENSG00000204882
  • ENST00000613887
  • ENSP00000479665
  • ENSG00000275181
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.77
cell type or tissue
0.59
PubMedID
0.58
cell line
0.47
transcription factor
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.1   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.1   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (147)
GPR27
Tbio
Family:  GPCR
Novelty:  0.164488
Score:  0.951
Data Source:  STRINGDB
GPR150
Tdark
Family:  GPCR
Novelty:  0.91287003
Score:  0.949
Data Source:  STRINGDB
GPR22
Tbio
Family:  GPCR
Novelty:  0.1822753
Score:  0.931
Data Source:  STRINGDB
GPR45
Tbio
Family:  GPCR
Novelty:  0.08366919
Score:  0.931
Data Source:  STRINGDB
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
Score:  0.93
Data Source:  STRINGDB
GPR176
Tbio
Family:  GPCR
Novelty:  0.28180289
Score:  0.93
Data Source:  STRINGDB
CRHR2
Tchem
Family:  GPCR
Novelty:  0.00245379
Score:  0.924
Data Source:  STRINGDB
GPR39
Tchem
Family:  GPCR
Novelty:  0.01244607
Score:  0.921
Data Source:  STRINGDB
GPR15
Tbio
Family:  GPCR
Novelty:  0.00673057
Score:  0.92
Data Source:  STRINGDB
GPR25
Tdark
Family:  GPCR
Novelty:  0.42142701
Score:  0.919
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
3
4
83
neutrophil count
4
3
4
83
leukocyte count
3
3
4
81.9
leukocyte count
3
3
4
81.9
platelet crit
2
3
3
80.8
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
83
neutrophil count
4
83
leukocyte count
4
81.9
leukocyte count
4
81.9
platelet crit
3
80.8
Find similar targets by:
IDG Resources
Items per page:
10
1 – 10 of 21
Genetic Construct
GPR20-Tango
image for GPR20-Tango
Details:
  • Vector:  addgene66344
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR20-Tango
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Genetic Construct
pcDNA3.1-GGamma13-GFP2
image for pcDNA3.1-GGamma13-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma9-GFP2
image for pcDNA3.1-GGamma9-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma8-GFP2
image for pcDNA3.1-GGamma8-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma1-GFP2
image for pcDNA3.1-GGamma1-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-Beta3
image for pcDNA3.1-Beta3
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
Order Genetic Construct from:
Genetic Construct
pcDNA3.1-Beta1
image for pcDNA3.1-Beta1
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
Order Genetic Construct from:
Genetic Construct
pcDNA5/FRT/TO-GAlpha13-RLuc8
image for pcDNA5/FRT/TO-GAlpha13-RLuc8
Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha12-RLuc8
image for pcDNA5/FRT/TO-GAlpha12-RLuc8
Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha15-RLuc8
image for pcDNA5/FRT/TO-GAlpha15-RLuc8
Details:
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Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 20
VGNC:50314
737712
Mouse
MGI:2441803
239530
Dog
G protein-coupled receptor 20
VGNC:41425
482061
Horse
G protein-coupled receptor 20
VGNC:18535
100069651
Cow
G protein-coupled receptor 20
VGNC:29579
515695
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 20
Mouse
Dog
G protein-coupled receptor 20
Horse
G protein-coupled receptor 20
Cow
G protein-coupled receptor 20
Publication Statistics
PubMed Score 3.10
PubMed score by year
PubTator Score 0.75
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title