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Tbio
GPR180
Integral membrane protein GPR180

Protein Summary
Description
This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376958
  • ENSP00000366157
  • ENSG00000152749

Symbol
  • ITR
  • ITR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
microRNA
0.8
cell line
0.71
transcription factor perturbation
0.61
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.19   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.19   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
SGCA
Tbio
Novelty:  0.00442268
p_int:  0.756351508
p_ni:  0.243648492
Score:  0.577
Data Source:  BioPlex,STRINGDB
SETMAR
Tbio
Family:  Epigenetic
Novelty:  0.02859547
Score:  0.907
Data Source:  STRINGDB
TGDS
Tbio
Family:  Enzyme
Novelty:  0.01813871
Score:  0.757
Data Source:  STRINGDB
PPP1R12C
Tdark
Family:  Enzyme
Novelty:  0.00465397
Score:  0.669
Data Source:  STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
Score:  0.645
Data Source:  STRINGDB
RPS9
Tbio
Novelty:  0.01329701
Score:  0.605
Data Source:  STRINGDB
PEX5L
Tbio
Novelty:  0.01922466
Score:  0.585
Data Source:  STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
Score:  0.555
Data Source:  STRINGDB
ETF1
Tbio
Family:  Enzyme
Novelty:  0.00711627
Score:  0.539
Data Source:  STRINGDB
GPR176
Tdark
Family:  GPCR
Novelty:  0.28180289
Score:  0.53
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
3
2
15.2
96.3
triglyceride measurement
5
5
5
90.2
sex hormone-binding globulin measurement
5
2
5
88
hair color
1
1
0
1.2
38.7
hair colour measurement
1
1
1
37.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
15.2
96.3
triglyceride measurement
5
90.2
sex hormone-binding globulin measurement
5
88
hair color
0
1.2
38.7
hair colour measurement
1
37.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor 180
694839
Mouse
MGI:1930949
58245
Rat
RGD:1359193
306165
Dog
G protein-coupled receptor 180
VGNC:41421
485522
Horse
G protein-coupled receptor 180
VGNC:18532
100059006
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor 180
Mouse
Rat
Dog
G protein-coupled receptor 180
Horse
G protein-coupled receptor 180
Publication Statistics
PubMed Score 53.19
PubMed score by year
PubTator Score 9.74
PubTator score by year
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Related Publications
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PMID
Year
Title