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Tbio
GPR171
Probable G-protein coupled receptor 171

Protein Summary
Description
Orphan receptor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309180
  • ENSP00000308479
  • ENSG00000174946
  • ENST00000617554
  • ENSP00000482588

Symbol
  • H963
  • H963
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
microRNA
0.77
tissue sample
0.56
PubMedID
0.55
cell line
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.98   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.98   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
OR56B4
Tdark
Family:  oGPCR
Novelty:  1.79104478
Score:  0.657
Data Source:  STRINGDB
OR52W1
Tdark
Family:  oGPCR
Novelty:  7.15909091
Score:  0.649
Data Source:  STRINGDB
OR56A3
Tdark
Family:  oGPCR
Novelty:  47
Score:  0.647
Data Source:  STRINGDB
OR52B2
Tdark
Family:  oGPCR
Novelty:  4.08934708
Score:  0.644
Data Source:  STRINGDB
OR56A1
Tdark
Family:  oGPCR
Novelty:  28
Score:  0.627
Data Source:  STRINGDB
OR56A4
Tdark
Family:  oGPCR
Novelty:  6.15286624
Score:  0.598
Data Source:  STRINGDB
CNGA4
Tbio
Family:  IC
Novelty:  0.05605027
Score:  0.594
Data Source:  STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.592
Data Source:  STRINGDB
GPR88
Tchem
Family:  GPCR
Novelty:  0.02963528
Score:  0.565
Data Source:  STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
Score:  0.552
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
2
2
2
66.8
lymphocyte count
1
1
1
65
myeloid white cell count
1
1
1
64.5
eosinophil count
3
2
3
59
insomnia measurement
1
1
0
1
26.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
2
66.8
lymphocyte count
1
65
myeloid white cell count
1
64.5
eosinophil count
3
59
insomnia measurement
0
1
26.8
IDG Resources
Items per page:
10
1 – 10 of 21
Genetic Construct
GPR171-Tango
image for GPR171-Tango
Details:
  • Vector:  addgene66337
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR171-Tango
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Genetic Construct
pcDNA3.1-GGamma13-GFP2
image for pcDNA3.1-GGamma13-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma9-GFP2
image for pcDNA3.1-GGamma9-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma8-GFP2
image for pcDNA3.1-GGamma8-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma1-GFP2
image for pcDNA3.1-GGamma1-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-Beta3
image for pcDNA3.1-Beta3
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-Beta1
image for pcDNA3.1-Beta1
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA5/FRT/TO-GAlpha13-RLuc8
image for pcDNA5/FRT/TO-GAlpha13-RLuc8
Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha12-RLuc8
image for pcDNA5/FRT/TO-GAlpha12-RLuc8
Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha15-RLuc8
image for pcDNA5/FRT/TO-GAlpha15-RLuc8
Details:
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Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 171
VGNC:11403
738791
Macaque
G protein-coupled receptor 171
709960
Mouse
MGI:2442043
229323
Rat
RGD:1585271
688737
Dog
G protein-coupled receptor 171
VGNC:41415
485716
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 171
Macaque
G protein-coupled receptor 171
Mouse
Rat
Dog
G protein-coupled receptor 171
Publication Statistics
PubMed Score 8.98
PubMed score by year
PubTator Score 3.45
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title