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Tbio
GPR162
Probable G-protein coupled receptor 162

Protein Summary
Description
Orphan receptor. This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311268
  • ENSP00000311528
  • ENSG00000250510
  • ENST00000428545
  • ENSP00000399670

Symbol
  • GRCA
  • A-2
  • GRCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
cellular component
0.67
kinase perturbation
0.66
histone modification site profile
0.65
cell type or tissue
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.42   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.42   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
GPR142
Tchem
Family:  GPCR
Novelty:  0.08800117
Score:  0.704
Data Source:  STRINGDB
GPR139
Tchem
Family:  GPCR
Novelty:  0.04083224
Score:  0.665
Data Source:  STRINGDB
UBXN11
Tbio
Novelty:  0.03165477
Score:  0.646
Data Source:  STRINGDB
GPR82
Tdark
Family:  GPCR
Novelty:  0.39696704
Score:  0.634
Data Source:  STRINGDB
GPR135
Tbio
Family:  GPCR
Novelty:  0.29123972
Score:  0.609
Data Source:  STRINGDB
GPR146
Tbio
Family:  GPCR
Novelty:  0.10269429
Score:  0.604
Data Source:  STRINGDB
GPR62
Tbio
Family:  GPCR
Novelty:  0.43474185
Score:  0.604
Data Source:  STRINGDB
ASPRV1
Tbio
Family:  Enzyme
Novelty:  0.0278626
Score:  0.602
Data Source:  STRINGDB
GPR101
Tbio
Family:  GPCR
Novelty:  0.04514552
Score:  0.595
Data Source:  STRINGDB
GPR61
Tbio
Family:  GPCR
Novelty:  0.11649666
Score:  0.581
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
2
9
86.1
refractive error measurement
2
1
1
7.8
82.4
age at onset
1
1
0
7.8
63.4
Myopia
3
1
0
1.3
63.4
ganglion cell inner plexiform layer thickness measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
9
86.1
refractive error measurement
1
7.8
82.4
age at onset
0
7.8
63.4
Myopia
0
1.3
63.4
ganglion cell inner plexiform layer thickness measurement
1
58.4
Find similar targets by:
IDG Resources
Genetic Construct
GPR162-Tango
image for GPR162-Tango
Details:
  • Vector:  addgene66335
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR162-Tango
Order Genetic Construct from:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 162
VGNC:8598
100611668
Mouse
MGI:1315214
14788
Rat
RGD:1307437
362436
Dog
G protein-coupled receptor 162
VGNC:41413
486719
Horse
G protein-coupled receptor 162
VGNC:18526
100146294
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 162
Mouse
Rat
Dog
G protein-coupled receptor 162
Horse
G protein-coupled receptor 162
Publication Statistics
PubMed Score 7.42
PubMed score by year
PubTator Score 41.78
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title