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Tdark
GPR157
G-protein coupled receptor 157

Protein Summary
Description
Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377411
  • ENSP00000366628
  • ENSG00000180758
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
cell type or tissue
0.74
tissue sample
0.59
protein domain
0.58
transcription factor
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
ADGRD1
Tbio
Family:  GPCR
Novelty:  0.08106046
Score:  0.772
Data Source:  STRINGDB
GPR137C
Tdark
Novelty:  3.30248948
Score:  0.766
Data Source:  STRINGDB
SLC2A5
Tbio
Family:  Transporter
Novelty:  0.0032733
Score:  0.745
Data Source:  STRINGDB
ADGRD2
Tdark
Family:  GPCR
Novelty:  1.00566581
Score:  0.649
Data Source:  STRINGDB
LZIC
Tdark
Novelty:  0.34151594
Score:  0.63
Data Source:  STRINGDB
QRFPR
Tchem
Family:  GPCR
Novelty:  0.03650642
Score:  0.626
Data Source:  STRINGDB
PTX3
Tbio
Novelty:  0.00153752
Score:  0.601
Data Source:  STRINGDB
TPRA1
Tdark
Family:  GPCR
Novelty:  0.16743826
Score:  0.6
Data Source:  STRINGDB
GPR174
Tchem
Family:  GPCR
Novelty:  0.09139622
Score:  0.595
Data Source:  STRINGDB
SLC25A33
Tbio
Family:  Transporter
Novelty:  0.17554778
Score:  0.594
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
1
2
77.9
granulocyte percentage of myeloid white cells
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
77.9
granulocyte percentage of myeloid white cells
1
56.4
IDG Resources
Genetic Construct
GPR157-Tango
image for GPR157-Tango
Details:
  • Vector:  addgene66331
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR157-Tango
Order Genetic Construct from:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 157
VGNC:11443
749268
Mouse
MGI:2442046
269604
Rat
RGD:1311096
313725
Dog
G protein-coupled receptor 157
VGNC:41409
608460
Horse
G protein-coupled receptor 157
VGNC:18522
100057687
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 157
Mouse
Rat
Dog
G protein-coupled receptor 157
Horse
G protein-coupled receptor 157
Publication Statistics
PubMed Score 1.22
PubMed score by year
PubTator Score 1.08
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title