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Tdark
GPR156
Probable G-protein coupled receptor 156

Protein Summary
Description
Orphan receptor. G protein-coupled receptors (GPCRs) are a large superfamily of cell surface receptors characterized by 7 helical transmembrane domains, together with N-terminal extracellular and C-terminal intracellular domains.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315843
  • ENSP00000324553
  • ENSG00000175697
  • ENST00000461057
  • ENSP00000418758
  • ENST00000464295
  • ENSP00000417261

Symbol
  • GABABL
  • PGR28
  • PGR28
  • GABABL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.69
microRNA
0.69
PubMedID
0.51
phenotype
0.5
tissue sample
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.96   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.96   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
ZNF564
Tdark
Family:  TF
Novelty:  23
p_int:  0.9999995
p_ni:  3.62e-7
p_wrong:  1.38e-7
Score:  0.171
Data Source:  BioPlex,STRINGDB
RPUSD2
Tdark
Family:  Enzyme
Novelty:  1.41606982
p_int:  0.999999078
p_ni:  9.22e-7
Data Source:  BioPlex
VANGL2
Tbio
Novelty:  0.00529796
p_int:  0.999995783
p_ni:  0.000004217
Data Source:  BioPlex
VANGL1
Tbio
Novelty:  0.00968008
p_int:  0.99999072
p_ni:  0.00000928
Data Source:  BioPlex
ZBTB1
Tbio
Family:  TF
Novelty:  0.33667235
p_int:  0.999989401
p_ni:  0.000010595
p_wrong:  3e-9
Data Source:  BioPlex
ZNF444
Tdark
Family:  TF
Novelty:  0.21564163
p_int:  0.999979768
p_ni:  0.000020232
Data Source:  BioPlex
NFKBIL1
Tbio
Novelty:  0.03932489
p_int:  0.999976044
p_ni:  0.000023956
Data Source:  BioPlex
AGAP3
Tbio
Family:  Enzyme
Novelty:  0.15649084
p_int:  0.999975733
p_ni:  0.000024267
p_wrong:  1e-9
Data Source:  BioPlex
PLD1
Tchem
Family:  Enzyme
Novelty:  0.00608142
p_int:  0.999966979
p_ni:  0.000033021
Score:  0.153
Data Source:  BioPlex,STRINGDB
FARP2
Tbio
Novelty:  0.09590913
p_int:  0.999923862
p_ni:  0.000076138
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
67.9
total cholesterol measurement
1
1
1
60.8
neutrophil count
2
2
2
54.8
monocyte count
1
1
1
39.7
alkaline phosphatase measurement
2
1
1
7.1
32.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
67.9
total cholesterol measurement
1
60.8
neutrophil count
2
54.8
monocyte count
1
39.7
alkaline phosphatase measurement
1
7.1
32.1
Find similar targets by:
IDG Resources
Items per page:
10
1 – 10 of 21
Genetic Construct
GPR156-Tango
image for GPR156-Tango
Details:
  • Vector:  addgene66330
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR156-Tango
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Genetic Construct
pcDNA3.1-GGamma13-GFP2
image for pcDNA3.1-GGamma13-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma9-GFP2
image for pcDNA3.1-GGamma9-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma8-GFP2
image for pcDNA3.1-GGamma8-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma1-GFP2
image for pcDNA3.1-GGamma1-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-Beta3
image for pcDNA3.1-Beta3
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-Beta1
image for pcDNA3.1-Beta1
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA5/FRT/TO-GAlpha13-RLuc8
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Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha12-RLuc8
image for pcDNA5/FRT/TO-GAlpha12-RLuc8
Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha15-RLuc8
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Details:
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Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 156
VGNC:7972
470896
Macaque
G protein-coupled receptor 156
713174
Mouse
MGI:2653880
239845
Rat
RGD:708438
260430
Dog
G protein-coupled receptor 156
VGNC:41408
488000
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 156
Macaque
G protein-coupled receptor 156
Mouse
Rat
Dog
G protein-coupled receptor 156
Publication Statistics
PubMed Score 3.96
PubMed score by year
PubTator Score 2.00
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title