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Tdark
GPR150
Probable G-protein coupled receptor 150

Protein Summary
Description
Orphan receptor. This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the vasopressin-like subfamily that also includes vasopressin and oxytocin receptors. The silencing of this gene, due to promoter methylation, is associated with ovarian cancer progression. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380007
  • ENSP00000369344
  • ENSG00000178015

Symbol
  • PGR11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.7
histone modification site profile
0.66
cell type or tissue
0.51
transcription factor binding site profile
0.51
tissue
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (148)
GPR83
Tchem
Family:  GPCR
Novelty:  0.03554942
Score:  0.977
Data Source:  STRINGDB
GPR25
Tdark
Family:  GPCR
Novelty:  0.42142701
Score:  0.949
Data Source:  STRINGDB
GPR20
Tdark
Family:  GPCR
Novelty:  0.34435286
Score:  0.949
Data Source:  STRINGDB
GPR176
Tdark
Family:  GPCR
Novelty:  0.28180289
Score:  0.949
Data Source:  STRINGDB
GPR27
Tbio
Family:  GPCR
Novelty:  0.164488
Score:  0.941
Data Source:  STRINGDB
GPR15
Tbio
Family:  GPCR
Novelty:  0.00673057
Score:  0.94
Data Source:  STRINGDB
GPR45
Tbio
Family:  GPCR
Novelty:  0.08366919
Score:  0.938
Data Source:  STRINGDB
GPR32
Tchem
Family:  GPCR
Novelty:  0.0551913
Score:  0.926
Data Source:  STRINGDB
VIP
Tbio
Novelty:  0.00024946
Score:  0.926
Data Source:  STRINGDB
GPR84
Tchem
Family:  GPCR
Novelty:  0.02360587
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
79.9
1
1
0
1.1
8.6
pulmonary function measurement
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
79.9
0
1.1
8.6
pulmonary function measurement
1
3.8
IDG Resources
Genetic Construct
GPR150-Tango
image for GPR150-Tango
Details:
  • Vector:  addgene66326
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR150-Tango
Order Genetic Construct from:
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 150
VGNC:11956
471477
Macaque
G protein-coupled receptor 150
698491
Mouse
MGI:2441872
238725
Rat
RGD:1564729
499486
Pig
G protein-coupled receptor 150
100516597
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 150
Macaque
G protein-coupled receptor 150
Mouse
Rat
Pig
G protein-coupled receptor 150
Publication Statistics
PubMed Score 1.07
PubMed score by year
PubTator Score 0.88
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title