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Tdark
GPR141
Probable G-protein coupled receptor 141

Protein Summary
Description
Orphan receptor. GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334425
  • ENSP00000334540
  • ENSG00000187037
  • ENST00000447769
  • ENSP00000390410

Symbol
  • PGR13
  • PGR13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.7
tissue
0.66
protein complex
0.4
cell type or tissue
0.37
cell line
0.35


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.21   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.21   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
CCNY
Tbio
Novelty:  0.01400663
p_int:  0.997553242
p_ni:  0.002441546
p_wrong:  0.000005211
Data Source:  BioPlex
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.987444341
p_ni:  0.012555653
p_wrong:  6e-9
Data Source:  BioPlex
TSPAN6
Tbio
Novelty:  0.11515803
p_int:  0.979303184
p_ni:  0.020686341
p_wrong:  0.000010476
Score:  0.173
Data Source:  BioPlex,STRINGDB
TTYH3
Tbio
Family:  IC
Novelty:  0.21747247
p_int:  0.960641163
p_ni:  0.039358837
Data Source:  BioPlex
STXBP3
Tbio
Novelty:  0.03346737
p_int:  0.912930646
p_ni:  0.087069354
Score:  0.666
Data Source:  BioPlex,STRINGDB
PAG1
Tbio
Novelty:  0.01390911
p_int:  0.902381522
p_ni:  0.09055721
p_wrong:  0.007061267
Data Source:  BioPlex
STX4
Tbio
Novelty:  0.00831588
p_int:  0.901772564
p_ni:  0.098226706
p_wrong:  7.3e-7
Score:  0.239
Data Source:  BioPlex,STRINGDB
AHNAK
Tbio
Novelty:  0.01201996
p_int:  0.841881851
p_ni:  0.158118149
Score:  0.185
Data Source:  BioPlex,STRINGDB
MT-CO1
Tchem
Family:  Enzyme
Novelty:  0.00008262
p_int:  0.826833473
p_ni:  0.173165719
p_wrong:  8.08e-7
Data Source:  BioPlex
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.817999077
p_ni:  0.182000923
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
9
98.4
Dupuytren Contracture
1
1
0
1.5
83.3
bone density
1
1
1
56.6
1
1
0
1.1
29
1
1
0
3.7
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
9
98.4
Dupuytren Contracture
0
1.5
83.3
bone density
1
56.6
0
1.1
29
0
3.7
28.1
Find similar targets by:
IDG Resources
Genetic Construct
GPR141-Tango
image for GPR141-Tango
Details:
  • Vector:  addgene66318
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR141-Tango
Order Genetic Construct from:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 141
VGNC:14074
463355
Mouse
MGI:2672983
353346
Rat
RGD:727906
291179
Dog
G protein-coupled receptor 141
VGNC:41401
482403
Horse
G protein-coupled receptor 141
VGNC:18513
100070650
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 141
Mouse
Rat
Dog
G protein-coupled receptor 141
Horse
G protein-coupled receptor 141
Publication Statistics
PubMed Score 3.21
PubMed score by year
PubTator Score 1.52
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title