You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GPR135
G-protein coupled receptor 135

Protein Summary
Description
Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395116
  • ENSP00000378548
  • ENSG00000181619
  • ENST00000481661
  • ENSP00000432696

Symbol
  • HUMNPIIY20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.7
cell type or tissue
0.58
tissue sample
0.56
cell line
0.53
tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.11   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.11   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
PTAFR
Tchem
Family:  GPCR
Novelty:  0.00755426
Score:  0.716
Data Source:  STRINGDB
GPR141
Tdark
Family:  GPCR
Novelty:  0.30711523
Score:  0.668
Data Source:  STRINGDB
GPR62
Tbio
Family:  GPCR
Novelty:  0.43474185
Score:  0.64
Data Source:  STRINGDB
GPR142
Tchem
Family:  GPCR
Novelty:  0.08800117
Score:  0.639
Data Source:  STRINGDB
TIMM9
Tbio
Family:  Enzyme
Novelty:  0.02996764
Score:  0.629
Data Source:  STRINGDB
GPR25
Tdark
Family:  GPCR
Novelty:  0.42142701
Score:  0.628
Data Source:  STRINGDB
FBXO34
Tdark
Novelty:  5.6683456
Score:  0.628
Data Source:  STRINGDB
GPR162
Tbio
Family:  GPCR
Novelty:  0.14938549
Score:  0.609
Data Source:  STRINGDB
OR6V1
Tdark
Family:  oGPCR
Novelty:  5.35714286
Score:  0.57
Data Source:  STRINGDB
PSMA3
Tbio
Family:  Enzyme
Novelty:  0.03106507
Score:  0.569
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
3
0
12.6
66.2
monocyte count
1
1
1
38.8
visual cortical surface area measurement
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
12.6
66.2
monocyte count
1
38.8
visual cortical surface area measurement
1
36.5
IDG Resources
Genetic Construct
GPR135-Tango
image for GPR135-Tango
Details:
  • Vector:  addgene66317
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR135-Tango
Order Genetic Construct from:
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2676315
238252
Rat
RGD:727844
314213
Cow
G protein-coupled receptor 135
VGNC:29549
781195
Xenopus
G protein-coupled receptor 135 [Source:Xenbase;Acc:XB-GENE-876945]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
G protein-coupled receptor 135
Xenopus
G protein-coupled receptor 135 [Source:Xenbase;Acc:XB-GENE-876945]
Publication Statistics
PubMed Score 3.11
PubMed score by year
PubTator Score 2.04
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title