GPR135
G-protein coupled receptor 135
Protein Summary
Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).
- ENST00000395116
- ENSP00000378548
- ENSG00000181619
- ENST00000481661
- ENSP00000432696
- HUMNPIIY20
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.7 | ||
cell type or tissue | 0.58 | ||
tissue sample | 0.56 | ||
cell line | 0.53 | ||
tissue | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.11 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 86 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.11 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 86 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (39)
Nearest Tclin Targets
Pathways (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | GPCRs, Other | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GPCRs, Other | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (2)
Components (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cortical surface area measurement | 1 | 3 | 0 | 12.6 | 66.2 | ||||
monocyte count | 1 | 1 | 1 | 38.8 | |||||
visual cortical surface area measurement | 1 | 1 | 1 | 36.5 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cortical surface area measurement | 0 | 12.6 | 66.2 | ||||
monocyte count | 1 | 38.8 | |||||
visual cortical surface area measurement | 1 | 36.5 | |||||
Find similar targets by:
IDG Resources
Reagents (1)
Genetic Construct
GPR135-Tango
Details:
- Vector: addgene66317
- Vector backbone: pcDNA3.1(+)
- Promoter: CMV
- Tag: FLAG
Data:
- GPR135-Tango
Order Genetic Construct from:
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2676315 | 238252 | ||||||
Rat | RGD:727844 | 314213 | ||||||
Cow | G protein-coupled receptor 135 | VGNC:29549 | 781195 | |||||
Xenopus | G protein-coupled receptor 135 [Source:Xenbase;Acc:XB-GENE-876945] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Cow | G protein-coupled receptor 135 | |||||
Xenopus | G protein-coupled receptor 135 [Source:Xenbase;Acc:XB-GENE-876945] | |||||
Publication Statistics
PubMed Score 3.11
PubMed score by year
PubTator Score 2.04
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (8)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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