GPNMB
Transmembrane glycoprotein NMB
Protein Summary
Could be a melanogenic enzyme. The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000258733
- ENSP00000258733
- ENSG00000136235
- ENST00000381990
- ENSP00000371420
- HGFIN
- NMB
- NMB
- HGFIN
- PLCA3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.96 | ||
transcription factor perturbation | 0.88 | ||
small molecule perturbation | 0.85 | ||
virus perturbation | 0.72 | ||
cellular component | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 252.8 (req: < 5)
Gene RIFs: 103 (req: <= 3)
Antibodies: 376 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 252.8 (req: >= 5)
Gene RIFs: 103 (req: > 3)
Antibodies: 376 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0