Protein Summary
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
- ENST00000264718
- ENSP00000264718
- ENSG00000198522
- ENST00000407583
- ENSP00000384255
- ENST00000424214
- ENSP00000398115
- ENST00000458167
- ENSP00000412170
- ENST00000503738
- ENSP00000427269
- ENST00000515877
- ENSP00000424678
- ENST00000610189
- ENSP00000476446
- ENST00000616939
- ENSP00000484680
- MBDIN
- RPAP4
- XAB1
- XAB1
- MBDIN
- NTPBP
- RPAP4
- ATPBD1A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 0.97 | ||
molecular function | 0.91 | ||
histone modification site profile | 0.84 | ||
transcription factor perturbation | 0.8 | ||
transcription factor binding site profile | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.39 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 178 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.39 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 178 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (102)
TMEM183A
Novelty: 0.4017284
p_int: 0.999999742
p_ni: 2.35e-7
p_wrong: 2.3e-8
Data Source: BioPlex
POLR3K
Family: Enzyme
Novelty: 0.07105011
p_int: 0.999920163
p_ni: 0.000078365
p_wrong: 0.000001472
Score: 0.183
Data Source: BioPlex,STRINGDB
RPAP2
Family: Enzyme
Novelty: 0.03383659
p_int: 0.999889175
p_ni: 0.000110825
Score: 0.941
Data Source: BioPlex,STRINGDB
POLR3E
Family: Enzyme
Novelty: 0.06500715
p_int: 0.999825078
p_ni: 0.000174922
Score: 0.196
Data Source: BioPlex,STRINGDB
POLR3D
Family: Enzyme
Novelty: 0.02616321
p_int: 0.999734888
p_ni: 0.000265046
p_wrong: 6.6e-8
Score: 0.331
Data Source: BioPlex,STRINGDB
RPAP1
Family: Enzyme
Novelty: 0.23737405
p_int: 0.99970116
p_ni: 0.00029884
Score: 0.942
Data Source: BioPlex,STRINGDB
CRCP
Family: Enzyme
Novelty: 0.01111812
p_int: 0.999527713
p_ni: 0.000467295
p_wrong: 0.000004992
Data Source: BioPlex
POLR3H
Family: Enzyme
Novelty: 0.16483597
p_int: 0.999343958
p_ni: 0.000655927
p_wrong: 1.15e-7
Score: 0.277
Data Source: BioPlex,STRINGDB
POLR3B
Family: Enzyme
Novelty: 0.02526167
p_int: 0.998836138
p_ni: 0.001163862
Score: 0.436
Data Source: BioPlex,STRINGDB
Q6EEV4
Family: Enzyme
Novelty: 0.11413088
p_int: 0.997350195
p_ni: 0.00264975
p_wrong: 5.6e-8
Score: 0.822
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (27)
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 5 | 9 | 10 | 97.2 | |||||
appendicular lean mass | 3 | 2 | 3 | 90.4 | |||||
C-reactive protein measurement | 1 | 3 | 3 | 89.3 | |||||
alcohol consumption measurement | 3 | 3 | 3 | 79.9 | |||||
apolipoprotein B measurement | 1 | 2 | 2 | 71.1 | |||||
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
triglyceride measurement | 10 | 97.2 | |||||
appendicular lean mass | 3 | 90.4 | |||||
C-reactive protein measurement | 3 | 89.3 | |||||
alcohol consumption measurement | 3 | 79.9 | |||||
apolipoprotein B measurement | 2 | 71.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | GPN-loop GTPase 1 | VGNC:263 | 470341 | |||||
Macaque | GPN-loop GTPase 1 | 701903 | ||||||
Mouse | MGI:1921504 | 74254 | ||||||
Rat | RGD:1589985 | 688393 | ||||||
Dog | GPN-loop GTPase 1-like | 608308 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | GPN-loop GTPase 1 | |||||
Macaque | GPN-loop GTPase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | GPN-loop GTPase 1-like | |||||
Publication Statistics
PubMed Score 14.39
PubMed score by year
PubTator Score 11.38
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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