Tbio GPN1 GPN-loop GTPase 1

Protein Summary

Description

Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q9HCN4
• B4DQJ5
• B4DQM4
• B4DXU4
• B5MBZ5
• O76004

Gene Name

• GPN1

Ensembl ID

• ENST00000264718
• ENSP00000264718
• ENSG00000198522
• ENST00000407583
• ENSP00000384255
• ENST00000424214
• ENSP00000398115
• ENST00000458167
• ENSP00000412170
• ENST00000503738
• ENSP00000427269
• ENST00000515877
• ENSP00000424678
• ENST00000610189
• ENSP00000476446
• ENST00000616939
• ENSP00000484680

Symbol

• MBDIN
• RPAP4
• XAB1
• XAB1
• MBDIN
• NTPBP
• RPAP4
• ATPBD1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.97
molecular function	0.91
histone modification site profile	0.84
transcription factor perturbation	0.8
transcription factor binding site profile	0.78

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Gpn-loop Gtpase 1

DTO Classes

Protein / Nucleic Acid Binding / Gpn-loop Gtpase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.39   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.39   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (102)

Explore Interacting Targets

1 – 10 of 102

• See Interactions on String-DB

TMEM183A

Tdark

Novelty:  0.4017284

p_int:  0.999999742

p_ni:  2.35e-7

p_wrong:  2.3e-8

Data Source:  BioPlex

POLR3K

Tbio

Family:  Enzyme

Novelty:  0.07105011

p_int:  0.999920163

p_ni:  0.000078365

p_wrong:  0.000001472

Score:  0.183

Data Source:  BioPlex,STRINGDB

RPAP2

Tbio

Family:  Enzyme

Novelty:  0.03383659

p_int:  0.999889175

p_ni:  0.000110825

Score:  0.941

Data Source:  BioPlex,STRINGDB

POLR3E

Tbio

Family:  Enzyme

Novelty:  0.06500715

p_int:  0.999825078

p_ni:  0.000174922

Score:  0.196

Data Source:  BioPlex,STRINGDB

POLR3D

Tbio

Family:  Enzyme

Novelty:  0.02616321

p_int:  0.999734888

p_ni:  0.000265046

p_wrong:  6.6e-8

Score:  0.331

Data Source:  BioPlex,STRINGDB

RPAP1

Tdark

Family:  Enzyme

Novelty:  0.23737405

p_int:  0.99970116

p_ni:  0.00029884

Score:  0.942

Data Source:  BioPlex,STRINGDB

CRCP

Tbio

Family:  Enzyme

Novelty:  0.01111812

p_int:  0.999527713

p_ni:  0.000467295

p_wrong:  0.000004992

Data Source:  BioPlex

POLR3H

Tbio

Family:  Enzyme

Novelty:  0.16483597

p_int:  0.999343958

p_ni:  0.000655927

p_wrong:  1.15e-7

Score:  0.277

Data Source:  BioPlex,STRINGDB

POLR3B

Tbio

Family:  Enzyme

Novelty:  0.02526167

p_int:  0.998836138

p_ni:  0.001163862

Score:  0.436

Data Source:  BioPlex,STRINGDB

Q6EEV4

Tbio

Family:  Enzyme

Novelty:  0.11413088

p_int:  0.997350195

p_ni:  0.00264975

p_wrong:  5.6e-8

Score:  0.822

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (2)

Components (3)

Find Similar Targets

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1 – 2 of 2

GO Term	Evidence	Assigned by
GTPase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GTP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (27)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 27

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	5	9	10		97.2
appendicular lean mass	EFO_0004980	3	2	3		90.4
C-reactive protein measurement	EFO_0004458	1	3	3		89.3
alcohol consumption measurement	EFO_0007878	3	3	3		79.9
apolipoprotein B measurement	EFO_0004615	1	2	2		71.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 27

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	10		97.2
appendicular lean mass	EFO_0004980	3		90.4
C-reactive protein measurement	EFO_0004458	3		89.3
alcohol consumption measurement	EFO_0007878	3		79.9
apolipoprotein B measurement	EFO_0004615	2		71.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
GTP-binding
Hydrolase
Nucleotide-binding
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
alcohol consumption measurement
alcohol drinking
apolipoprotein B measurement
appendicular lean mass
aspartate aminotransferase measurement
biological sex
BMI-adjusted fasting blood glucose measurement
BMI-adjusted fasting blood insulin measurement
C-reactive protein measurement
coffee consumption measurement

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	GPN-loop GTPase 1	VGNC:263	470341
Macaque	GPN-loop GTPase 1		701903
Mouse	GPN-loop GTPase 1	MGI:1921504	74254
Rat	GPN-loop GTPase 1	RGD:1589985	688393
Dog	GPN-loop GTPase 1-like		608308

Species	Name	OMA	EggNOG	Inparanoid
Chimp	GPN-loop GTPase 1
Macaque	GPN-loop GTPase 1
Mouse	GPN-loop GTPase 1
Rat	GPN-loop GTPase 1
Dog	GPN-loop GTPase 1-like

Publication Statistics

PubMed Score 14.39

PubMed score by year

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PubTator Score 11.38

PubTator score by year

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Related Publications

Text Mined References (19)

GeneRif Annotations (9)

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10

0 of 0

PMID	Year	Title