Tbio GPN1 GPN-loop GTPase 1

Protein Summary

Description

Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q9HCN4
• B4DQJ5
• B4DQM4
• B4DXU4
• B5MBZ5
• O76004

Gene Name

• GPN1

Ensembl ID

• ENST00000264718
• ENSP00000264718
• ENSG00000198522
• ENST00000407583
• ENSP00000384255
• ENST00000424214
• ENSP00000398115
• ENST00000458167
• ENSP00000412170
• ENST00000503738
• ENSP00000427269
• ENST00000515877
• ENSP00000424678
• ENST00000610189
• ENSP00000476446
• ENST00000616939
• ENSP00000484680

Symbol

• MBDIN
• RPAP4
• XAB1
• XAB1
• MBDIN
• NTPBP
• RPAP4
• ATPBD1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.97
molecular function	0.91
histone modification site profile	0.84
transcription factor perturbation	0.8
transcription factor binding site profile	0.78

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Gpn-loop Gtpase 1

DTO Classes

Protein / Nucleic Acid Binding / Gpn-loop Gtpase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.54   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.54   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0