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Tbio
GPM6A
Neuronal membrane glycoprotein M6-a

Protein Summary
Description
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280187
  • ENSP00000280187
  • ENSG00000150625
  • ENST00000393658
  • ENSP00000377268
  • ENST00000506894
  • ENSP00000421578
  • ENST00000515090
  • ENSP00000423984

Symbol
  • M6A
  • M6A
  • GPM6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
gene perturbation
0.88
transcription factor perturbation
0.88
PubMedID
0.82
transcription factor
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.95   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.95   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
CCDC126
Tdark
Novelty:  1.97527673
p_int:  0.999999737
p_ni:  2.63e-7
p_wrong:  1e-9
Score:  0.217
Data Source:  BioPlex,STRINGDB
MGAT5
Tbio
Family:  Enzyme
Novelty:  0.00707747
p_int:  0.999569104
p_ni:  0.000430891
p_wrong:  6e-9
Data Source:  BioPlex
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.998892051
p_ni:  0.001107949
Data Source:  BioPlex
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.997221291
p_ni:  0.002778705
p_wrong:  3e-9
Data Source:  BioPlex
IKBIP
Tbio
Family:  Enzyme
Novelty:  0.18707639
p_int:  0.995029591
p_ni:  0.004970409
Data Source:  BioPlex
FITM2
Tdark
Novelty:  0.01882177
p_int:  0.994222402
p_ni:  0.005777292
p_wrong:  3.05e-7
Score:  0.309
Data Source:  BioPlex,STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.99292293
p_ni:  0.006966742
p_wrong:  0.000110327
Data Source:  BioPlex
ARMC1
Tbio
Novelty:  0.02018109
p_int:  0.992862554
p_ni:  0.007011862
p_wrong:  0.000125584
Data Source:  BioPlex
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.978602508
p_ni:  0.0099534
p_wrong:  0.011444091
Data Source:  BioPlex
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.975221656
p_ni:  0.024747925
p_wrong:  0.000030419
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
5
4
1
89.5
mathematical ability
2
3
3
78.9
8
7
1
1.1
71.3
smoking status measurement
2
1
2
38.2
household income
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
1
89.5
mathematical ability
3
78.9
1
1.1
71.3
smoking status measurement
2
38.2
household income
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycoprotein M6A
VGNC:607
742345
Macaque
glycoprotein M6A
698488
Mouse
MGI:107671
234267
Rat
RGD:631368
306439
Dog
glycoprotein M6A
VGNC:41385
475641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycoprotein M6A
Macaque
glycoprotein M6A
Mouse
Rat
Dog
glycoprotein M6A
Publication Statistics
PubMed Score 35.95
PubMed score by year
PubTator Score 147.05
PubTator score by year
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Related Publications
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PMID
Year
Title