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Tbio
GPLD1
Phosphatidylinositol-glycan-specific phospholipase D

Protein Summary
Description
This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
0.81
co-expressed gene
0.69
phenotype
0.66
gene perturbation
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.61   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.61   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.995967385
p_ni:  7.17e-7
p_wrong:  0.004031898
Score:  0.232
Data Source:  BioPlex,STRINGDB
ALPL
Tchem
Family:  Enzyme
Novelty:  0.00152281
Score:  0.947
Data Source:  STRINGDB
PIGW
Tbio
Novelty:  0.0245774
Score:  0.927
Data Source:  STRINGDB
CEACAM5
Tbio
Novelty:  0.00007291
Score:  0.923
Data Source:  STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.919
Data Source:  STRINGDB
VNN1
Tchem
Family:  Enzyme
Novelty:  0.0144646
Score:  0.919
Data Source:  STRINGDB
NTNG1
Tbio
Novelty:  0.04742965
Score:  0.918
Data Source:  STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
Score:  0.915
Data Source:  STRINGDB
ALPG
Tchem
Family:  Enzyme
Novelty:  0.00577814
Score:  0.91
Data Source:  STRINGDB
ALPI
Tchem
Family:  Enzyme
Novelty:  0.00559196
Score:  0.909
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
5
9
7
18.4
99.7
liver enzyme measurement
1
1
1
50.6
uric acid measurement
1
1
1
49.5
serum alanine aminotransferase measurement
1
1
1
49.5
creatine kinase measurement
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
7
18.4
99.7
liver enzyme measurement
1
50.6
uric acid measurement
1
49.5
serum alanine aminotransferase measurement
1
49.5
creatine kinase measurement
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycosylphosphatidylinositol specific phospholipase D1
VGNC:2848
462473
Mouse
MGI:106604
14756
Rat
RGD:631371
291132
Dog
glycosylphosphatidylinositol specific phospholipase D1
VGNC:41384
478735
Horse
glycosylphosphatidylinositol specific phospholipase D1
VGNC:18497
100067517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycosylphosphatidylinositol specific phospholipase D1
Mouse
Rat
Dog
glycosylphosphatidylinositol specific phospholipase D1
Horse
glycosylphosphatidylinositol specific phospholipase D1
Publication Statistics
PubMed Score 169.61
PubMed score by year
PubTator Score 849.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title