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Tbio
GPHA2
Glycoprotein hormone alpha-2

Protein Summary
Description
Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258). Plays a central role in controlling thyroid cell metabolism (PubMed:12045258). GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279168
  • ENSP00000279168
  • ENSG00000149735
  • ENST00000533257
  • ENSP00000432918

Symbol
  • GPA2
  • ZSIG51
  • A2
  • GPA2
  • ZSIG51
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.62
hub protein
0.49
cell type or tissue
0.46
cell line
0.45
metabolite
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.14   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.14   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
FAAP100
Tdark
Novelty:  0.1698504
p_int:  0.99996072
p_ni:  0.00003928
Data Source:  BioPlex
GPT2
Tbio
Family:  Enzyme
Novelty:  0.00478585
p_int:  0.99991993
p_ni:  0.000080033
p_wrong:  3.7e-8
Score:  0.303
Data Source:  BioPlex,STRINGDB
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.999438969
p_ni:  0.000561031
Data Source:  BioPlex
EPHA6
Tchem
Family:  Kinase
Novelty:  0.02713974
p_int:  0.983181308
p_ni:  0.000972073
p_wrong:  0.015846619
Score:  0.303
Data Source:  BioPlex,STRINGDB
FRAS1
Tbio
Novelty:  0.02114063
p_int:  0.977878501
p_ni:  0.022121499
Data Source:  BioPlex
PLXNA2
Tbio
Novelty:  0.01765957
p_int:  0.976850304
p_ni:  0.023149696
Data Source:  BioPlex
CNTNAP3
Tbio
Novelty:  0.22791524
p_int:  0.957962596
p_ni:  0.042037404
Data Source:  BioPlex
ADAM9
Tchem
Family:  Enzyme
Novelty:  0.00616626
p_int:  0.942302769
p_ni:  0.057697212
p_wrong:  1.9e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
ANKRD46
Tbio
Novelty:  0.06546845
p_int:  0.934047609
p_ni:  0.065905526
p_wrong:  0.000046865
Data Source:  BioPlex
LAMB2
Tbio
Novelty:  0.07966931
p_int:  0.836038853
p_ni:  0.163961147
Score:  0.158
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hormone ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Hormone ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
1
1
69
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
69
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycoprotein hormone alpha 2
VGNC:11791
744235
Macaque
glycoprotein hormone alpha 2
717261
Mouse
MGI:2156541
170458
Cow
glycoprotein hormone alpha 2
VGNC:29533
617578
Pig
glycoprotein hormone alpha 2
100516058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycoprotein hormone alpha 2
Macaque
glycoprotein hormone alpha 2
Mouse
Cow
glycoprotein hormone alpha 2
Pig
glycoprotein hormone alpha 2
Publication Statistics
PubMed Score 101.14
PubMed score by year
PubTator Score 72.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title