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Tbio
GPD1L
Glycerol-3-phosphate dehydrogenase 1-like protein

Protein Summary
Description
Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS). [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282541
  • ENSP00000282541
  • ENSG00000152642

Symbol
  • KIAA0089
  • GPD1-L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.91
transcription factor perturbation
0.8
molecular function
0.79
tissue sample
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.23   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.23   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (161)
GPD1
Tbio
Family:  Enzyme
Novelty:  0.00584133
p_int:  0.999699366
p_ni:  0.000300634
Score:  0.87
Data Source:  BioPlex,STRINGDB
FAS
Tbio
Novelty:  0.00043286
p_int:  0.996436452
p_ni:  0.003563548
Data Source:  BioPlex
SLC3A2
Tbio
Family:  Transporter
Novelty:  0.0021506
p_int:  0.995064068
p_ni:  0.004935931
Data Source:  BioPlex
ISLR
Tbio
Novelty:  0.02936208
p_int:  0.987459069
p_ni:  0.012540931
Data Source:  BioPlex
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.978115344
p_ni:  0.021884656
Score:  0.258
Data Source:  BioPlex,STRINGDB
TGOLN2
Tbio
Novelty:  0.005107
p_int:  0.976279938
p_ni:  0.023720062
Data Source:  BioPlex
CST8
Tbio
Novelty:  0.02316886
p_int:  0.966843016
p_ni:  0.033156984
Data Source:  BioPlex
MICB
Tbio
Novelty:  0.00364639
p_int:  0.920389667
p_ni:  0.079610333
Data Source:  BioPlex
FAM174A
Tdark
Novelty:  0.30693139
p_int:  0.853482076
p_ni:  0.146517924
Data Source:  BioPlex
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.849212964
p_ni:  0.150787036
Data Source:  BioPlex
Pathways (11)
Glycerophospholipid biosynthesis (R-HSA-1483206)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PA
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
39.5
cognitive function measurement
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
39.5
cognitive function measurement
1
27.3
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glycerol-3-phosphate dehydrogenase 1 like
707723
Mouse
MGI:1289257
333433
Rat
RGD:1560123
363159
Dog
glycerol-3-phosphate dehydrogenase 1 like
VGNC:41377
485626
Horse
glycerol-3-phosphate dehydrogenase 1 like
VGNC:18489
100057124
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glycerol-3-phosphate dehydrogenase 1 like
Mouse
Rat
Dog
glycerol-3-phosphate dehydrogenase 1 like
Horse
glycerol-3-phosphate dehydrogenase 1 like
Publication Statistics
PubMed Score 56.23
PubMed score by year
PubTator Score 12.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title