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Tbio
GPC6
Glypican-6

Protein Summary
Description
Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling. The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377047
  • ENSP00000366246
  • ENSG00000183098

Symbol
  • OMIMD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
pathway
0.97
interacting protein
0.85
transcription factor perturbation
0.84
PubMedID
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.94   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.94   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
GPC4
Tbio
Novelty:  0.01319626
p_int:  0.999999995
p_ni:  5e-9
Score:  0.984
Data Source:  BioPlex,STRINGDB
HADHA
Tbio
Novelty:  0.00385746
p_int:  0.993974773
p_ni:  0.006025227
Data Source:  BioPlex
GPR183
Tchem
Family:  GPCR
Novelty:  0.02005679
p_int:  0.975205987
p_ni:  0.024794013
Score:  0.538
Data Source:  BioPlex,STRINGDB
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.917063826
p_ni:  0.082936174
Score:  0.22
Data Source:  BioPlex,STRINGDB
DLX4
Tbio
Family:  TF
Novelty:  0.01959238
p_int:  0.879617943
p_ni:  0.120382057
Score:  0.372
Data Source:  BioPlex,STRINGDB
MRPS7
Tbio
Novelty:  0.00153134
p_int:  0.879617943
p_ni:  0.120382057
Score:  0.186
Data Source:  BioPlex,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
Score:  0.978
Data Source:  STRINGDB
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.976
Data Source:  STRINGDB
EXT1
Tbio
Family:  Enzyme
Novelty:  0.00355951
Score:  0.97
Data Source:  STRINGDB
SDC1
Tbio
Novelty:  0.00044792
Score:  0.969
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Reactome
Defective B3GAT3 causes JDSSDHD
Reactome
Defective B4GALT7 causes EDS, progeroid type
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Defective B3GAT3 causes JDSSDHD
Defective B4GALT7 causes EDS, progeroid type
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
9
12
96.8
chronotype measurement
2
2
1
1
71.8
wellbeing measurement
3
2
3
52.3
refractive error measurement
2
2
1
6.2
40.5
depressive symptom measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
12
96.8
chronotype measurement
1
1
71.8
wellbeing measurement
3
52.3
refractive error measurement
1
6.2
40.5
depressive symptom measurement
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glypican 6
VGNC:13111
452621
Mouse
MGI:1346322
23888
Chicken
glypican 6
CGNC:12684
418794
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glypican 6
Mouse
Chicken
glypican 6
Publication Statistics
PubMed Score 46.94
PubMed score by year
PubTator Score 16.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title