Tbio GPC5 Glypican-5

Protein Summary

Description

Cell surface proteoglycan that bears heparan sulfate. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P78333
• B2R726
• O60436
• Q9BX27

Gene Name

• GPC5

Ensembl ID

• ENST00000377067
• ENSP00000366267
• ENSG00000179399

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
pathway	0.98
virus perturbation	0.83
disease	0.77
phenotype	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.6   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.6   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0