Protein Summary
Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division ...more
- ENST00000264039
- ENSP00000264039
- ENSG00000063660
- glypican
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cellular component | 0.91 | ||
PubMedID | 0.88 | ||
transcription factor perturbation | 0.84 | ||
gene perturbation | 0.83 | ||
biological process | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 359.7 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 291 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 359.7 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 291 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (184)
GPR183
Family: GPCR
Novelty: 0.02005679
p_int: 0.999999528
p_ni: 4.72e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
CAMKV
Family: Kinase
Novelty: 0.17794181
p_int: 0.999998743
p_ni: 0.000001255
p_wrong: 2e-9
Data Source: BioPlex
HADHB
Family: Enzyme
Novelty: 0.00969194
p_int: 0.999988623
p_ni: 0.000011377
Score: 0.173
Data Source: BioPlex,STRINGDB
FGF1
Novelty: 0.00055979
p_int: 0.999973568
p_ni: 0.000026428
p_wrong: 4e-9
Score: 0.455
Data Source: BioPlex,STRINGDB
USP3
Family: Enzyme
Novelty: 0.02331328
p_int: 0.999900865
p_ni: 0.000008558
p_wrong: 0.000090577
Score: 0.237
Data Source: BioPlex,STRINGDB
LRRTM4
Novelty: 0.07741851
p_int: 0.999675416
p_ni: 0.000077635
p_wrong: 0.000246949
Score: 0.647
Data Source: BioPlex,STRINGDB
FANCE
Novelty: 0.04484113
p_int: 0.997813997
p_ni: 0.002185393
p_wrong: 6.1e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
ATP2B4
Family: Transporter
Novelty: 0.00560356
p_int: 0.994688868
p_ni: 0.005311132
Score: 0.159
Data Source: BioPlex,STRINGDB
TMEM245
Novelty: 0.30094854
p_int: 0.97341259
p_ni: 0.026418663
p_wrong: 0.000168747
Score: 0.161
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (45)
Reactome (29)
KEGG (2)
PathwayCommons (10)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Reactome | Axon guidance | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Axon guidance | ||||
Cell surface interactions at the vascular wall | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (3)
Components (15)
Processes (10)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 1 | 1 | 1 | 49.5 | |||||
balding measurement | 1 | 1 | 1 | 12.6 | |||||
response to selective serotonin reuptake inhibitor | 1 | 1 | 0 | 62.8 | 0.4 | ||||
body mass index | 1 | 1 | 0 | 62.8 | 0.4 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean platelet volume | 1 | 49.5 | |||||
balding measurement | 1 | 12.6 | |||||
response to selective serotonin reuptake inhibitor | 0 | 62.8 | 0.4 | ||||
body mass index | 0 | 62.8 | 0.4 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:1194891 | 14733 | ||||||
Rat | RGD:61853 | 58920 | ||||||
Dog | glypican 1 | VGNC:49902 | 486197 | |||||
Horse | glypican 1 [Source:HGNC Symbol;Acc:HGNC:4449] | |||||||
Cow | glypican 1 | VGNC:29523 | 518114 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | glypican 1 | |||||
Horse | glypican 1 [Source:HGNC Symbol;Acc:HGNC:4449] | |||||
Cow | glypican 1 | |||||
Publication Statistics
PubMed Score 359.70
PubMed score by year
PubTator Score 122.55
PubTator score by year
Related Publications
Text Mined References (51)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
---|