Tbio GPC1 Glypican-1

Protein Summary

Description

Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35052
• B3KTD1
• Q53QM4

Gene Name

• GPC1

Ensembl ID

• ENST00000264039
• ENSP00000264039
• ENSG00000063660

Symbol

• glypican

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.91
PubMedID	0.88
transcription factor perturbation	0.84
gene perturbation	0.83
biological process	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.7   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 291   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.7   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (184)

Explore Interacting Targets

1 – 10 of 184

• See Interactions on String-DB

HADHA

Tbio

Novelty:  0.00385746

p_int:  0.999999993

p_ni:  6e-9

Data Source:  BioPlex

GPR183

Tchem

Family:  GPCR

Novelty:  0.02005679

p_int:  0.999999528

p_ni:  4.72e-7

Score:  0.187

Data Source:  BioPlex,STRINGDB

CAMKV

Tbio

Family:  Kinase

Novelty:  0.17794181

p_int:  0.999998743

p_ni:  0.000001255

p_wrong:  2e-9

Data Source:  BioPlex

HADHB

Tbio

Family:  Enzyme

Novelty:  0.00969194

p_int:  0.999988623

p_ni:  0.000011377

Score:  0.173

Data Source:  BioPlex,STRINGDB

FGF1

Tchem

Novelty:  0.00055979

p_int:  0.999973568

p_ni:  0.000026428

p_wrong:  4e-9

Score:  0.455

Data Source:  BioPlex,STRINGDB

USP3

Tbio

Family:  Enzyme

Novelty:  0.02331328

p_int:  0.999900865

p_ni:  0.000008558

p_wrong:  0.000090577

Score:  0.237

Data Source:  BioPlex,STRINGDB

LRRTM4

Tbio

Novelty:  0.07741851

p_int:  0.999675416

p_ni:  0.000077635

p_wrong:  0.000246949

Score:  0.647

Data Source:  BioPlex,STRINGDB

FANCE

Tbio

Novelty:  0.04484113

p_int:  0.997813997

p_ni:  0.002185393

p_wrong:  6.1e-7

Score:  0.188

Data Source:  BioPlex,STRINGDB

ATP2B4

Tbio

Family:  Transporter

Novelty:  0.00560356

p_int:  0.994688868

p_ni:  0.005311132

Score:  0.159

Data Source:  BioPlex,STRINGDB

TMEM245

Tdark

Novelty:  0.30094854

p_int:  0.97341259

p_ni:  0.026418663

p_wrong:  0.000168747

Score:  0.161

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Downstream (2)

1 – 2 of 2

EGFR

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  1

1: Proteoglycans in cancer

FGFR1

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  1

1: Proteoglycans in cancer

Pathways (45)

Reactome (29)

KEGG (2)

PathwayCommons (10)

WikiPathways (4)

A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

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Items per page:

5

1 – 5 of 29

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Reactome	Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332

Name	Explore in Pharos	Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Axon guidance	533 targets	R-HSA-422475
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (28)

Functions (3)

Components (15)

Processes (10)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
copper ion binding	Inferred from Direct Assay (IDA)	UniProtKB
fibroblast growth factor binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
laminin binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (4)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1	1	1		49.5
balding measurement	EFO_0007825	1	1	1		12.6
response to selective serotonin reuptake inhibitor	EFO_0005658	1	1	0	62.8	0.4
body mass index	EFO_0004340	1	1	0	62.8	0.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1		49.5
balding measurement	EFO_0007825	1		12.6
response to selective serotonin reuptake inhibitor	EFO_0005658	0	62.8	0.4
body mass index	EFO_0004340	0	62.8	0.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Copper
Direct protein sequencing
Disulfide bond
Endosome
Glycoprotein
GPI-anchor

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
body mass index
mean platelet volume
response to selective serotonin reuptake inhibitor

MGI Phenotype Find Similar Targets

No Header	No Header
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	glypican 1	MGI:1194891	14733
Rat	glypican 1	RGD:61853	58920
Dog	glypican 1	VGNC:49902	486197
Horse	glypican 1 [Source:HGNC Symbol;Acc:HGNC:4449]
Cow	glypican 1	VGNC:29523	518114

Species	Name	OMA	EggNOG	Inparanoid
Mouse	glypican 1
Rat	glypican 1
Dog	glypican 1
Horse	glypican 1 [Source:HGNC Symbol;Acc:HGNC:4449]
Cow	glypican 1

Publication Statistics

PubMed Score 359.70

PubMed score by year

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PubTator Score 122.55

PubTator score by year

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Related Publications

Text Mined References (51)

GeneRif Annotations (31)

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10

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PMID	Year	Title