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Tdark
GPATCH2
G patch domain-containing protein 2

Protein Summary
Description
Enhances the ATPase activity of DHX15 in vitro. The gene encodes a nuclear factor that may play a role in spermatogenesis and in tumor growth during breast cancer. The encoded protein contains a G-patch domain with an RNA binding motif. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366934
  • ENSP00000355901
  • ENSG00000092978
  • ENST00000366935
  • ENSP00000355902

Symbol
  • GPATC2
  • Pfa1
  • CT110
  • GPATC2
  • PPP1R30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
drug perturbation
0.87
histone modification site profile
0.83
kinase perturbation
0.76
tissue sample
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.87   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.87   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  1
Score:  0.178
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999999596
p_ni:  1.1e-8
p_wrong:  3.93e-7
Data Source:  BioPlex
LRP5
Tbio
Novelty:  0.00089807
p_int:  0.999702904
p_ni:  0.000297096
Data Source:  BioPlex
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.998923003
p_ni:  4.36e-7
p_wrong:  0.001076561
Data Source:  BioPlex
LRP6
Tbio
Novelty:  0.00305615
p_int:  0.997534825
p_ni:  0.002465175
Data Source:  BioPlex
PICK1
Tbio
Novelty:  0.0058265
p_int:  0.908259612
p_ni:  0.000042788
p_wrong:  0.0916976
Score:  0.187
Data Source:  BioPlex,STRINGDB
TFIP11
Tbio
Novelty:  0.01546496
Score:  0.861
Data Source:  STRINGDB
DHX15
Tbio
Family:  Enzyme
Novelty:  0.0134377
Score:  0.822
Data Source:  STRINGDB
NOB1
Tbio
Novelty:  0.01209681
Score:  0.731
Data Source:  STRINGDB
IGSF11
Tbio
Novelty:  0.07516371
Score:  0.7
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
42.3
age at onset
1
1
1
31.4
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
42.3
age at onset
1
31.4
1
31.4
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G-patch domain containing 2
VGNC:6844
457739
Macaque
G-patch domain containing 2
708081
Mouse
MGI:1915019
67769
Dog
G-patch domain containing 2
VGNC:41365
488594
Horse
G-patch domain containing 2
VGNC:18478
100050453
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G-patch domain containing 2
Macaque
G-patch domain containing 2
Mouse
Dog
G-patch domain containing 2
Horse
G-patch domain containing 2
Publication Statistics
PubMed Score 31.87
PubMed score by year
PubTator Score 1.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title