Tdark GPATCH2 G patch domain-containing protein 2

Protein Summary

Description

Enhances the ATPase activity of DHX15 in vitro. The gene encodes a nuclear factor that may play a role in spermatogenesis and in tumor growth during breast cancer. The encoded protein contains a G-patch domain with an RNA binding motif. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Uniprot Accession IDs

• Q9NW75
• Q5VYK7
• Q5VYK8
• Q86YE7

Gene Name

• GPATCH2

Ensembl ID

• ENST00000366934
• ENSP00000355901
• ENSG00000092978
• ENST00000366935
• ENSP00000355902

Symbol

• GPATC2
• Pfa1
• CT110
• GPATC2
• PPP1R30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
drug perturbation	0.87
histone modification site profile	0.83
kinase perturbation	0.76
tissue sample	0.69

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / G Patch Domain-containing Protein 2

DTO Classes

Protein / Nucleic Acid Binding / G Patch Domain-containing Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.8   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 48   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.8   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0