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Tbio
GPAT4
Glycerol-3-phosphate acyltransferase 4

Protein Summary
Description
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs. Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396987
  • ENSP00000380184
  • ENSG00000158669

Symbol
  • AGPAT6
  • TSARG7
  • AGPAT6
  • LPAATZ
  • TSARG7
  • 1-AGPAT 6
  • LPAAT-zeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.11   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.11   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
EHD2
Tbio
Novelty:  0.02724854
p_int:  0.995671939
p_ni:  0.00430934
p_wrong:  0.000018721
Score:  0.549
Data Source:  BioPlex,STRINGDB
GSDME
Tbio
Novelty:  0.01231123
p_int:  0.925531832
p_ni:  0.074468168
Score:  0.297
Data Source:  BioPlex,STRINGDB
MBOAT2
Tbio
Family:  Enzyme
Novelty:  0.01820899
Score:  0.975
Data Source:  STRINGDB
AGPAT1
Tbio
Family:  Enzyme
Novelty:  0.05245441
Score:  0.972
Data Source:  STRINGDB
AGPAT2
Tchem
Family:  Enzyme
Novelty:  0.01321334
Score:  0.972
Data Source:  STRINGDB
AGPAT3
Tbio
Family:  Enzyme
Novelty:  0.06139822
Score:  0.971
Data Source:  STRINGDB
AGPAT5
Tbio
Family:  Enzyme
Novelty:  0.23785857
Score:  0.969
Data Source:  STRINGDB
GPAM
Tbio
Family:  Enzyme
Novelty:  0.00973127
Score:  0.967
Data Source:  STRINGDB
AGPAT4
Tbio
Family:  Enzyme
Novelty:  0.10376004
Score:  0.963
Data Source:  STRINGDB
LCLAT1
Tbio
Family:  Enzyme
Novelty:  0.03234576
Score:  0.962
Data Source:  STRINGDB
Pathways (12)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PA
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PA
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
7
7
99.4
mean reticulocyte volume
1
5
5
99.2
11
7
5
1.1
98.8
reticulocyte count
6
4
14
98.5
reticulocyte measurement
3
4
7
98.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
7
99.4
mean reticulocyte volume
5
99.2
5
1.1
98.8
reticulocyte count
14
98.5
reticulocyte measurement
7
98.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycerol-3-phosphate acyltransferase 4
VGNC:3013
464140
Macaque
glycerol-3-phosphate acyltransferase 4
710363
Mouse
MGI:2142716
102247
Rat
RGD:1310520
290843
Dog
glycerol-3-phosphate acyltransferase 4
VGNC:49765
111090276
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycerol-3-phosphate acyltransferase 4
Macaque
glycerol-3-phosphate acyltransferase 4
Mouse
Rat
Dog
glycerol-3-phosphate acyltransferase 4
Publication Statistics
PubMed Score 33.11
PubMed score by year
PubTator Score 8.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title