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Tbio
GPAT3
Glycerol-3-phosphate acyltransferase 3

Protein Summary
Description
May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid, or PA). This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264409
  • ENSP00000264409
  • ENSG00000138678
  • ENST00000395226
  • ENSP00000378651
  • ENST00000611707
  • ENSP00000482571

Symbol
  • AGPAT9
  • MAG1
  • MAG1
  • AGPAT8
  • AGPAT9
  • AGPAT10
  • AGPAT 10
  • HMFN0839
  • LPAAT-theta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.15   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.15   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
SLC6A15
Tchem
Family:  Transporter
Novelty:  0.04011524
p_int:  0.975632841
p_ni:  0.024367159
Score:  0.324
Data Source:  BioPlex,STRINGDB
AGPAT1
Tbio
Family:  Enzyme
Novelty:  0.05245441
Score:  0.973
Data Source:  STRINGDB
AGPAT2
Tchem
Family:  Enzyme
Novelty:  0.01321334
Score:  0.972
Data Source:  STRINGDB
AGPAT5
Tbio
Family:  Enzyme
Novelty:  0.23785857
Score:  0.97
Data Source:  STRINGDB
GPAM
Tbio
Family:  Enzyme
Novelty:  0.00973127
Score:  0.97
Data Source:  STRINGDB
AGPAT3
Tbio
Family:  Enzyme
Novelty:  0.06139822
Score:  0.963
Data Source:  STRINGDB
MBOAT2
Tbio
Family:  Enzyme
Novelty:  0.01820899
Score:  0.962
Data Source:  STRINGDB
GPAT2
Tbio
Family:  Enzyme
Novelty:  0.03807198
Score:  0.96
Data Source:  STRINGDB
LCLAT1
Tbio
Family:  Enzyme
Novelty:  0.03234576
Score:  0.958
Data Source:  STRINGDB
AGPAT4
Tbio
Family:  Enzyme
Novelty:  0.10376004
Score:  0.957
Data Source:  STRINGDB
Pathways (52)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PA
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PA
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
1
2
75.1
heel bone mineral density
2
1
2
56.6
upper aerodigestive tract neoplasm
1
1
0
1.1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
75.1
heel bone mineral density
2
56.6
upper aerodigestive tract neoplasm
0
1.1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycerol-3-phosphate acyltransferase 3
VGNC:2020
461204
Mouse
MGI:3603816
231510
Rat
RGD:1565703
305166
Chicken
glycerol-3-phosphate acyltransferase 3
CGNC:51788
422610
Zebrafish
ZDB-GENE-040718-436
436958
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycerol-3-phosphate acyltransferase 3
Mouse
Rat
Chicken
glycerol-3-phosphate acyltransferase 3
Zebrafish
Publication Statistics
PubMed Score 33.15
PubMed score by year
PubTator Score 33.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title