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Tbio
GPAT2
Glycerol-3-phosphate acyltransferase 2, mitochondrial

Protein Summary
Description
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359548
  • ENSP00000352547
  • ENSG00000186281
  • ENST00000434632
  • ENSP00000389395

Symbol
  • CT123
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
cellular component
0.68
cell line
0.59
tissue sample
0.56
tissue
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.83   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.83   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
HSP90AB3P
Tdark
p_int:  0.991954945
p_ni:  0.008045055
Data Source:  BioPlex
BAG5
Tbio
Novelty:  0.0318404
p_int:  0.902142979
p_ni:  0.097857021
Data Source:  BioPlex
MUL1
Tbio
Family:  Enzyme
Novelty:  0.00841786
p_int:  0.767550498
p_ni:  0.232425282
p_wrong:  0.00002422
Data Source:  BioPlex
AGPAT2
Tchem
Family:  Enzyme
Novelty:  0.01321334
Score:  0.965
Data Source:  STRINGDB
AGPAT1
Tbio
Family:  Enzyme
Novelty:  0.05245441
Score:  0.961
Data Source:  STRINGDB
GPAT3
Tbio
Family:  Enzyme
Novelty:  0.03251979
Score:  0.96
Data Source:  STRINGDB
AGPAT5
Tbio
Family:  Enzyme
Novelty:  0.23785857
Score:  0.957
Data Source:  STRINGDB
GPAT4
Tbio
Family:  Enzyme
Novelty:  0.03409111
Score:  0.957
Data Source:  STRINGDB
MBOAT2
Tbio
Family:  Enzyme
Novelty:  0.01820899
Score:  0.955
Data Source:  STRINGDB
AGPAT4
Tbio
Family:  Enzyme
Novelty:  0.10376004
Score:  0.952
Data Source:  STRINGDB
Pathways (14)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PA
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PA
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of granulocytes
1
1
1
31.4
neutrophil percentage of granulocytes
1
1
1
29.8
monocyte percentage of leukocytes
1
1
1
13.6
diastolic blood pressure
1
1
1
13
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of granulocytes
1
31.4
neutrophil percentage of granulocytes
1
29.8
monocyte percentage of leukocytes
1
13.6
diastolic blood pressure
1
13
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glycerol-3-phosphate acyltransferase 2, mitochondrial
707076
Mouse
MGI:2684962
215456
Rat
RGD:1304904
296130
Dog
glycerol-3-phosphate acyltransferase 2, mitochondrial
VGNC:41362
100856013
Horse
glycerol-3-phosphate acyltransferase 2, mitochondrial
VGNC:18473
100062528
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glycerol-3-phosphate acyltransferase 2, mitochondrial
Mouse
Rat
Dog
glycerol-3-phosphate acyltransferase 2, mitochondrial
Horse
glycerol-3-phosphate acyltransferase 2, mitochondrial
Publication Statistics
PubMed Score 25.83
PubMed score by year
PubTator Score 4.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title