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Tbio
GPAM
Glycerol-3-phosphate acyltransferase 1, mitochondrial

Protein Summary
Description
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348367
  • ENSP00000265276
  • ENSG00000119927

Symbol
  • GPAT1
  • KIAA1560
  • GPAT
  • GPAT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
histone modification site profile
0.91
virus perturbation
0.88
disease perturbation
0.79
microRNA
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.01   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.01   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.999998645
p_ni:  5.51e-7
p_wrong:  8.03e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
SIRT2
Tchem
Family:  Epigenetic
Novelty:  0.00093962
p_int:  0.999998495
p_ni:  0.000001238
p_wrong:  2.67e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.999521418
p_ni:  0.00002081
p_wrong:  0.000457772
Data Source:  BioPlex
PSMC4
Tchem
Family:  Enzyme
Novelty:  0.01717597
p_int:  0.999514365
p_ni:  0.00005178
p_wrong:  0.000433855
Score:  0.161
Data Source:  BioPlex,STRINGDB
AGPAT2
Tchem
Family:  Enzyme
Novelty:  0.01321334
Score:  0.979
Data Source:  STRINGDB
AGPAT1
Tbio
Family:  Enzyme
Novelty:  0.05245441
Score:  0.978
Data Source:  STRINGDB
GPAT3
Tbio
Family:  Enzyme
Novelty:  0.03251979
Score:  0.97
Data Source:  STRINGDB
GPAT4
Tbio
Family:  Enzyme
Novelty:  0.03409111
Score:  0.967
Data Source:  STRINGDB
AGPAT3
Tbio
Family:  Enzyme
Novelty:  0.06139822
Score:  0.963
Data Source:  STRINGDB
AGPAT4
Tbio
Family:  Enzyme
Novelty:  0.10376004
Score:  0.959
Data Source:  STRINGDB
Pathways (31)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
ESR-mediated signaling
Estrogen-dependent gene expression
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
8
13
23
98.8
apolipoprotein A 1 measurement
2
5
5
97.7
total cholesterol measurement
7
9
19
91.3
low density lipoprotein cholesterol measurement
6
9
17
90.9
alkaline phosphatase measurement
3
2
2
12.3
87.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
23
98.8
apolipoprotein A 1 measurement
5
97.7
total cholesterol measurement
19
91.3
low density lipoprotein cholesterol measurement
17
90.9
alkaline phosphatase measurement
2
12.3
87.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycerol-3-phosphate acyltransferase, mitochondrial
VGNC:4697
450738
Macaque
glycerol-3-phosphate acyltransferase, mitochondrial
696042
Mouse
MGI:109162
14732
Rat
RGD:61847
29653
Dog
glycerol-3-phosphate acyltransferase, mitochondrial
VGNC:41360
486890
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycerol-3-phosphate acyltransferase, mitochondrial
Macaque
glycerol-3-phosphate acyltransferase, mitochondrial
Mouse
Rat
Dog
glycerol-3-phosphate acyltransferase, mitochondrial
Publication Statistics
PubMed Score 113.01
PubMed score by year
PubTator Score 51.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title