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Tchem
GP6
Platelet glycoprotein VI

Protein Summary
Description
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310373
  • ENSP00000308782
  • ENSG00000088053
  • ENST00000333884
  • ENSP00000334552
  • ENST00000417454
  • ENSP00000394922
  • ENST00000612184
  • ENSP00000479873
  • ENSG00000277439
  • ENST00000616456
  • ENSP00000483314
  • ENST00000622279
  • ENSP00000484029

Symbol
  • GPIV
  • GPVI
  • BDPLT11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.93
cellular component
0.79
disease
0.78
cell type or tissue
0.75
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1194.79   (req: < 5)
Gene RIFs: 149   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1194.79   (req: >= 5)
Gene RIFs: 149   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (88)
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.976
Data Source:  Reactome,STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.971
Data Source:  Reactome,STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.969
Data Source:  Reactome,STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.966
Data Source:  Reactome,STRINGDB
LCP2
Tbio
Novelty:  0.00512968
Score:  0.957
Data Source:  STRINGDB
MPIG6B
Tbio
Novelty:  0.04808462
Score:  0.954
Data Source:  STRINGDB
LAT
Tbio
Novelty:  0.00738419
Score:  0.949
Data Source:  STRINGDB
VAV1
Tchem
Novelty:  0.00180518
Score:  0.934
Data Source:  STRINGDB
VAV3
Tbio
Novelty:  0.010944
Score:  0.932
Data Source:  STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.93
Data Source:  STRINGDB
Pathways (7)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
GPVI-mediated activation cascade
Reactome
Hemostasis
Reactome
Platelet Adhesion to exposed collagen
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
GPVI-mediated activation cascade
Hemostasis
Platelet Adhesion to exposed collagen
Platelet activation, signaling and aggregation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet reactivity measurement
1
1
1
92.9
platelet reactivity measurement
1
1
1
92.9
blood protein measurement
1
3
3
90
blood protein measurement
1
3
3
90
mean platelet volume
3
3
4
89.1
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet reactivity measurement
1
92.9
platelet reactivity measurement
1
92.9
blood protein measurement
3
90
blood protein measurement
3
90
mean platelet volume
4
89.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 1194.79
PubMed score by year
PubTator Score 497.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title