You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GOT2
Aspartate aminotransferase, mitochondrial

Protein Summary
Description
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245206
  • ENSP00000245206
  • ENSG00000125166
  • ENST00000434819
  • ENSP00000394100

Symbol
  • KAT4
  • KATIV
  • KYAT4
  • mitAAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
cellular component
0.89
disease perturbation
0.83
virus perturbation
0.83
tissue sample
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1528.92   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 591   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1528.92   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 591   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (247)
MDH2
Tchem
Family:  Enzyme
Novelty:  0.00217694
Score:  0.993
Data Source:  STRINGDB
GLUD1
Tbio
Family:  Enzyme
Novelty:  0.00301109
Score:  0.986
Data Source:  STRINGDB
MDH1
Tchem
Family:  Enzyme
Novelty:  0.00203876
Score:  0.979
Data Source:  STRINGDB
GLUD2
Tbio
Family:  Enzyme
Novelty:  0.01470266
Score:  0.973
Data Source:  STRINGDB
GPT2
Tbio
Family:  Enzyme
Novelty:  0.00478585
Score:  0.964
Data Source:  STRINGDB
ASNS
Tchem
Family:  Enzyme
Novelty:  0.00337445
Score:  0.963
Data Source:  STRINGDB
GPT
Tbio
Family:  Enzyme
Novelty:  0.00003498
Score:  0.962
Data Source:  STRINGDB
IDH2
Tclin
Family:  Enzyme
Novelty:  0.00131782
Score:  0.955
Data Source:  STRINGDB
IDH1
Tclin
Family:  Enzyme
Novelty:  0.0004831
Score:  0.95
Data Source:  STRINGDB
CAD
Tchem
Novelty:  0.00651422
Score:  0.947
Data Source:  STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
Pathways (37)
Aspartate and asparagine metabolism (R-HSA-8963693)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aspartate and asparagine metabolism
Reactome
Degradation of cysteine and homocysteine
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glutamate and glutamine metabolism
Name
Explore in Pharos
Explore in Source
Aspartate and asparagine metabolism
Degradation of cysteine and homocysteine
Gluconeogenesis
Glucose metabolism
Glutamate and glutamine metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
3
3
2
13.4
92.2
blood metabolite measurement
2
2
2
77.1
serum alanine aminotransferase measurement
1
1
1
53.7
3
3
0
1.1
44
liver fibrosis measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
2
13.4
92.2
blood metabolite measurement
2
77.1
serum alanine aminotransferase measurement
1
53.7
0
1.1
44
liver fibrosis measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamic-oxaloacetic transaminase 2
VGNC:5779
467989
Macaque
glutamic-oxaloacetic transaminase 2
707896
Mouse
MGI:95792
14719
Rat
RGD:2722
25721
Dog
glutamic-oxaloacetic transaminase 2
478103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamic-oxaloacetic transaminase 2
Macaque
glutamic-oxaloacetic transaminase 2
Mouse
Rat
Dog
glutamic-oxaloacetic transaminase 2
Publication Statistics
PubMed Score 1528.92
PubMed score by year
PubTator Score 199.23
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title