Tbio GOT2 Aspartate aminotransferase, mitochondrial

Protein Summary

Description

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Uniprot Accession IDs

• P00505
• B4DJA6
• E7ERW2
• Q53FL3
• Q9BWA3
• mAspAT

Gene Name

• GOT2

Ensembl ID

• ENST00000245206
• ENSP00000245206
• ENSG00000125166
• ENST00000434819
• ENSP00000394100

Symbol

• KAT4
• KATIV
• KYAT4
• mitAAT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.93
cellular component	0.89
disease perturbation	0.83
virus perturbation	0.83
tissue sample	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1632.09   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 591   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1632.09   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 591   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0