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Tbio
GOSR1
Golgi SNAP receptor complex member 1

Protein Summary
Description
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225724
  • ENSP00000225724
  • ENSG00000108587
  • ENST00000467337
  • ENSP00000462638

Symbol
  • GS28
  • P28
  • GS28
  • GOS28
  • GOLIM2
  • GOS-28
  • GOS28/P28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
histone modification site profile
0.9
virus perturbation
0.9
transcription factor binding site profile
0.86
interacting protein
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.61   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.61   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (216)
STX7
Tbio
Novelty:  0.03109969
p_int:  0.999999379
p_ni:  6.21e-7
Score:  0.93
Data Source:  BioPlex,STRINGDB
STX12
Tbio
Novelty:  0.03836262
p_int:  0.999999338
p_ni:  6.62e-7
Score:  0.982
Data Source:  BioPlex,STRINGDB
TNFSF11
Tclin
Novelty:  0.00018328
p_int:  0.999999102
p_ni:  8.98e-7
Score:  0.243
Data Source:  BioPlex,STRINGDB
VAMP5
Tbio
Novelty:  0.09958312
p_int:  0.999982964
p_ni:  0.000017033
p_wrong:  4e-9
Score:  0.947
Data Source:  BioPlex,STRINGDB
SEC22B
Tbio
Novelty:  0.03035448
p_int:  0.999811668
p_ni:  0.000188332
Score:  0.995
Data Source:  BioPlex,STRINGDB
STX6
Tbio
Novelty:  0.01494028
p_int:  0.999798718
p_ni:  0.000201282
Score:  0.99
Data Source:  BioPlex,STRINGDB
STX11
Tbio
Novelty:  0.01670743
p_int:  0.999275907
p_ni:  0.000724093
Score:  0.751
Data Source:  BioPlex,STRINGDB
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.999262145
p_ni:  0.000737833
p_wrong:  2.2e-8
Data Source:  BioPlex
KIR2DL1
Tbio
Novelty:  0.00523657
p_int:  0.999131105
p_ni:  0.000867019
p_wrong:  0.000001877
Data Source:  BioPlex
STX3
Tbio
Novelty:  0.01055819
p_int:  0.996272539
p_ni:  0.00372746
Score:  0.939
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
59.4
high density lipoprotein cholesterol measurement
1
1
1
57.3
self reported educational attainment
1
1
1
40.7
cognitive function measurement
1
1
1
17.8
BMI-adjusted hip circumference
1
1
1
5.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
59.4
high density lipoprotein cholesterol measurement
1
57.3
self reported educational attainment
1
40.7
cognitive function measurement
1
17.8
BMI-adjusted hip circumference
1
5.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgi SNAP receptor complex member 1
VGNC:9306
450112
Macaque
golgi SNAP receptor complex member 1
574268
Mouse
MGI:1858260
53334
Rat
RGD:71093
94189
Dog
golgi SNAP receptor complex member 1
VGNC:41353
491185
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgi SNAP receptor complex member 1
Macaque
golgi SNAP receptor complex member 1
Mouse
Rat
Dog
golgi SNAP receptor complex member 1
Publication Statistics
PubMed Score 31.61
PubMed score by year
PubTator Score 160.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title