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Tbio
GORASP2
Golgi reassembly-stacking protein 2

Protein Summary
Description
Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234160
  • ENSP00000234160
  • ENSG00000115806

Symbol
  • GOLPH6
  • p59
  • GRS2
  • GOLPH6
  • GRASP55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.99
transcription factor binding site profile
0.95
transcription factor perturbation
0.94
tissue sample
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.65   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.65   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
BLZF1
Tbio
Novelty:  0.04344183
p_int:  0.999999972
p_ni:  2.8e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
KIF14
Tbio
Novelty:  0.02313641
p_int:  0.999968493
p_ni:  0.000031507
Score:  0.554
Data Source:  BioPlex,STRINGDB
GOLGA2
Tbio
Novelty:  0.00544771
p_int:  0.99958445
p_ni:  0.00041555
Score:  0.985
Data Source:  BioPlex,STRINGDB
ISCA1
Tbio
Novelty:  0.01288069
p_int:  0.994421632
p_ni:  0.0045811
p_wrong:  0.000997268
Score:  0.165
Data Source:  BioPlex,STRINGDB
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.970414739
p_ni:  0.029585243
p_wrong:  1.8e-8
Score:  0.563
Data Source:  BioPlex,STRINGDB
KIF1BP
Tbio
Novelty:  0.03932922
p_int:  0.935849807
p_ni:  0.064150193
Score:  0.307
Data Source:  BioPlex,STRINGDB
TMED4
Tdark
Novelty:  0.22372593
p_int:  0.919099488
p_ni:  0.080900512
Score:  0.445
Data Source:  BioPlex,STRINGDB
FLOT2
Tbio
Novelty:  0.00727325
p_int:  0.899605181
p_ni:  0.100394819
Score:  0.221
Data Source:  BioPlex,STRINGDB
FLOT1
Tbio
Novelty:  0.00504569
p_int:  0.751504255
p_ni:  0.248495745
Score:  0.622
Data Source:  BioPlex,STRINGDB
RAB2A
Tchem
Family:  Enzyme
Novelty:  0.00629151
Score:  0.986
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Golgi Cisternae Pericentriolar Stack Reorganization
Reactome
M Phase
Reactome
Mitotic Prophase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Golgi Cisternae Pericentriolar Stack Reorganization
M Phase
Mitotic Prophase
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
65.4
alkaline phosphatase measurement
1
1
1
60.5
mathematical ability
2
2
2
53.1
serum non-albumin protein measurement
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
65.4
alkaline phosphatase measurement
1
60.5
mathematical ability
2
53.1
serum non-albumin protein measurement
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgi reassembly stacking protein 2
VGNC:6365
459728
Macaque
golgi reassembly stacking protein 2
694170
Mouse
MGI:2135962
70231
Rat
RGD:619911
113961
Dog
golgi reassembly stacking protein 2
VGNC:41352
488395
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgi reassembly stacking protein 2
Macaque
golgi reassembly stacking protein 2
Mouse
Rat
Dog
golgi reassembly stacking protein 2
Publication Statistics
PubMed Score 59.65
PubMed score by year
PubTator Score 28.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title