Tbio GORASP2 Golgi reassembly-stacking protein 2

Protein Summary

Description

Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q9H8Y8
• B4DKT0
• Q53TE3
• Q96I74
• Q96K84
• Q9H946
• Q9UFW4
• GRS2

Gene Name

• GORASP2

Ensembl ID

• ENST00000234160
• ENSP00000234160
• ENSG00000115806

Symbol

• GOLPH6
• p59
• GRS2
• GOLPH6
• GRASP55

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
kinase perturbation	0.99
transcription factor binding site profile	0.95
transcription factor perturbation	0.94
tissue sample	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.65   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 273   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.65   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (97)

Explore Interacting Targets

1 – 10 of 97

• See Interactions on String-DB

BLZF1

Tbio

Novelty:  0.04344183

p_int:  0.999999972

p_ni:  2.8e-8

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

KIF14

Tbio

Novelty:  0.02313641

p_int:  0.999968493

p_ni:  0.000031507

Score:  0.554

Data Source:  BioPlex,STRINGDB

GOLGA2

Tbio

Novelty:  0.00544771

p_int:  0.99958445

p_ni:  0.00041555

Score:  0.985

Data Source:  BioPlex,STRINGDB

ISCA1

Tbio

Novelty:  0.01288069

p_int:  0.994421632

p_ni:  0.0045811

p_wrong:  0.000997268

Score:  0.165

Data Source:  BioPlex,STRINGDB

TMED7

Tdark

Novelty:  0.31193294

p_int:  0.970414739

p_ni:  0.029585243

p_wrong:  1.8e-8

Score:  0.563

Data Source:  BioPlex,STRINGDB

KIF1BP

Tbio

Novelty:  0.03932922

p_int:  0.935849807

p_ni:  0.064150193

Score:  0.307

Data Source:  BioPlex,STRINGDB

TMED4

Tdark

Novelty:  0.22372593

p_int:  0.919099488

p_ni:  0.080900512

Score:  0.445

Data Source:  BioPlex,STRINGDB

FLOT2

Tbio

Novelty:  0.00727325

p_int:  0.899605181

p_ni:  0.100394819

Score:  0.221

Data Source:  BioPlex,STRINGDB

FLOT1

Tbio

Novelty:  0.00504569

p_int:  0.751504255

p_ni:  0.248495745

Score:  0.622

Data Source:  BioPlex,STRINGDB

RAB2A

Tchem

Family:  Enzyme

Novelty:  0.00629151

Score:  0.986

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (5)

Cell Cycle (R-HSA-1640170)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Golgi Cisternae Pericentriolar Stack Reorganization	14 targets	R-HSA-162658
Reactome	M Phase	350 targets	R-HSA-68886
Reactome	Mitotic Prophase	113 targets	R-HSA-68875

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Golgi Cisternae Pericentriolar Stack Reorganization	14 targets	R-HSA-162658
M Phase	350 targets	R-HSA-68886
Mitotic Prophase	113 targets	R-HSA-68875

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Components (4)

Processes (7)

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1 – 4 of 4

GO Term	Evidence	Assigned by
endoplasmic reticulum membrane	Inferred from Direct Assay (IDA)	UniProtKB
Golgi apparatus	Inferred from Direct Assay (IDA)	UniProtKB
Golgi membrane	Inferred from Direct Assay (IDA)	UniProtKB
membrane	Traceable Author Statement (TAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (4)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	2	2	2		65.4
alkaline phosphatase measurement	EFO_0004533	1	1	1		60.5
mathematical ability	EFO_0004875	2	2	2		53.1
serum non-albumin protein measurement	EFO_0004568	1	1	1		5.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	2		65.4
alkaline phosphatase measurement	EFO_0004533	1		60.5
mathematical ability	EFO_0004875	2		53.1
serum non-albumin protein measurement	EFO_0004568	1		5.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Differentiation
Direct protein sequencing
Endoplasmic reticulum
Golgi apparatus
Lipoprotein
Membrane
Methylation

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
mathematical ability
mean platelet volume
serum non-albumin protein measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
growth/size/body region phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	golgi reassembly stacking protein 2	VGNC:6365	459728
Macaque	golgi reassembly stacking protein 2		694170
Mouse	golgi reassembly stacking protein 2	MGI:2135962	70231
Rat	golgi reassembly stacking protein 2	RGD:619911	113961
Dog	golgi reassembly stacking protein 2	VGNC:41352	488395

Species	Name	OMA	EggNOG	Inparanoid
Chimp	golgi reassembly stacking protein 2
Macaque	golgi reassembly stacking protein 2
Mouse	golgi reassembly stacking protein 2
Rat	golgi reassembly stacking protein 2
Dog	golgi reassembly stacking protein 2

Publication Statistics

PubMed Score 59.65

PubMed score by year

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PubTator Score 28.14

PubTator score by year

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Related Publications

Text Mined References (37)

GeneRif Annotations (12)

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PMID	Year	Title