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Tbio
GORASP1
Golgi reassembly-stacking protein 1

Protein Summary
Description
Plays an important role in assembly and membrane stacking of the Golgi cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (PubMed:26363069). Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319283
  • ENSP00000313869
  • ENSG00000114745
  • ENST00000431601
  • ENSP00000403552
  • ENST00000452389
  • ENSP00000403167

Symbol
  • GOLPH5
  • GRASP65
  • P65
  • GOLPH5
  • GRASP65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
histone modification site profile
0.74
tissue sample
0.68
kinase perturbation
0.66
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.97   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.97   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (234)
GOLGA2
Tbio
Novelty:  0.00544771
p_int:  0.999999999
p_ni:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
CLIP1
Tbio
Novelty:  0.00399891
p_int:  0.999999996
p_ni:  4e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
BLZF1
Tbio
Novelty:  0.04344183
p_int:  0.999996939
p_ni:  0.000003061
Score:  0.986
Data Source:  BioPlex,STRINGDB
TES
Tbio
Novelty:  0.00052221
p_int:  0.999993623
p_ni:  0.000006376
p_wrong:  1e-9
Data Source:  BioPlex
USP46
Tbio
Family:  Enzyme
Novelty:  0.04594593
p_int:  0.999947185
p_ni:  0.000052811
p_wrong:  5e-9
Data Source:  BioPlex
CCNJ
Tbio
Novelty:  0.14349559
p_int:  0.999940687
p_wrong:  0.000059312
Score:  0.158
Data Source:  BioPlex,STRINGDB
PPP6R2
Tbio
Family:  Enzyme
Novelty:  0.12886225
p_int:  0.999243852
p_ni:  0.000756148
Data Source:  BioPlex
SLX4IP
Tbio
Novelty:  0.25359409
p_int:  0.999203106
p_ni:  0.000796891
p_wrong:  3e-9
Data Source:  BioPlex
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.999061566
p_ni:  0.000938434
Score:  0.164
Data Source:  BioPlex,STRINGDB
ALDH1A3
Tchem
Family:  Enzyme
Novelty:  0.00691116
p_int:  0.998850106
p_ni:  0.000403913
p_wrong:  0.000745981
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
COPII-mediated vesicle transport
Cell Cycle
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
60.5
platelet crit
1
1
1
57.8
platelet count
1
1
1
54.4
metabolic syndrome
1
1
1
15.8
apolipoprotein A 1 measurement
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
60.5
platelet crit
1
57.8
platelet count
1
54.4
metabolic syndrome
1
15.8
apolipoprotein A 1 measurement
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgi reassembly stacking protein 1
VGNC:1831
747594
Macaque
golgi reassembly stacking protein 1
694728
Mouse
MGI:1921748
74498
Rat
RGD:621122
56082
Dog
golgi reassembly stacking protein 1
VGNC:41351
485594
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgi reassembly stacking protein 1
Macaque
golgi reassembly stacking protein 1
Mouse
Rat
Dog
golgi reassembly stacking protein 1
Publication Statistics
PubMed Score 47.97
PubMed score by year
PubTator Score 52.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title