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Tbio
GORAB
RAB6-interacting golgin

Protein Summary
Description
This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367762
  • ENSP00000356736
  • ENSG00000120370
  • ENST00000367763
  • ENSP00000356737

Symbol
  • NTKLBP1
  • SCYL1BP1
  • GO
  • NTKLBP1
  • SCYL1BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
microRNA
0.8
cell type or tissue
0.79
transcription factor
0.74
transcription factor binding site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.26   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.26   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.999999986
p_wrong:  1.4e-8
Score:  0.182
Data Source:  BioPlex,STRINGDB
IL17RE
Tbio
Novelty:  0.07568341
p_int:  0.999999702
p_ni:  2.97e-7
p_wrong:  1e-9
Score:  0.269
Data Source:  BioPlex,STRINGDB
CADPS
Tbio
Novelty:  0.01737775
p_int:  0.998731627
p_ni:  0.000014006
p_wrong:  0.001254367
Data Source:  BioPlex
SCYL1
Tbio
Family:  Kinase
Novelty:  0.03774351
Score:  0.946
Data Source:  STRINGDB
RCHY1
Tbio
Novelty:  0.01853663
Score:  0.911
Data Source:  STRINGDB
RAB6A
Tchem
Family:  Enzyme
Novelty:  0.00546034
Score:  0.773
Data Source:  STRINGDB
PYCR1
Tbio
Family:  Enzyme
Novelty:  0.00220832
Score:  0.72
Data Source:  STRINGDB
GCC1
Tbio
Novelty:  0.0844824
Score:  0.716
Data Source:  STRINGDB
TMEM53
Tdark
Novelty:  0.75877723
Score:  0.714
Data Source:  STRINGDB
KNCN
Tdark
Novelty:  0.21368805
Score:  0.693
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Sequence or structural Similarity (ISS)
HGNC
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
5
0
1.1
94.9
waist-hip ratio
1
4
4
92.3
BMI-adjusted waist-hip ratio
1
4
4
92.2
hip circumference
1
3
3
82.2
1
1
1
72.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
94.9
waist-hip ratio
4
92.3
BMI-adjusted waist-hip ratio
4
92.2
hip circumference
3
82.2
1
72.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgin, RAB6 interacting
VGNC:10026
469578
Macaque
golgin, RAB6 interacting
702571
Mouse
MGI:2138271
98376
Rat
RGD:1564990
304923
Dog
golgin, RAB6 interacting
VGNC:41350
490349
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgin, RAB6 interacting
Macaque
golgin, RAB6 interacting
Mouse
Rat
Dog
golgin, RAB6 interacting
Publication Statistics
PubMed Score 20.26
PubMed score by year
PubTator Score 9.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title