You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
GON7
EKC/KEOPS complex subunit GON7

Protein Summary
Description
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306954
  • ENSP00000306320
  • ENSG00000170270
  • ENST00000621279
  • ENSP00000478863
  • ENSG00000275619

Symbol
  • PNAS-127
  • C14orf142
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.85   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.85   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (11)
OSGEP
Tbio
Family:  Enzyme
Novelty:  0.0106198
p_int:  0.999999955
p_ni:  4.5e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.999999927
p_ni:  6.7e-8
p_wrong:  5e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
TP53RK
Tbio
Family:  Kinase
Novelty:  0.04302252
p_int:  0.999999501
p_ni:  4.97e-7
p_wrong:  2e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
TPRKB
Tbio
Novelty:  0.1035085
Score:  0.99
Data Source:  STRINGDB
OSGEPL1
Tbio
Family:  Enzyme
Novelty:  0.13592288
Score:  0.911
Data Source:  STRINGDB
YRDC
Tdark
Novelty:  0.01240103
Score:  0.79
Data Source:  STRINGDB
TRMO
Tbio
Novelty:  0.18313621
Score:  0.766
Data Source:  STRINGDB
SH2D2A
Tbio
Novelty:  0.02356634
Score:  0.584
Data Source:  STRINGDB
P0DPB6
Tbio
Family:  Enzyme
Novelty:  0.01598347
Score:  0.559
Data Source:  STRINGDB
P0DPB5
Tbio
Novelty:  0.01598347
Score:  0.559
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
1
1
1
5.3
hormone measurement
1
1
1
5.3
2
1
0
1
3.9
2
1
0
1
3.9
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
1
5.3
hormone measurement
1
5.3
0
1
3.9
0
1
3.9
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GON7, KEOPS complex subunit
453124
Mouse
MGI:4845848
100233175
Rat
RGD:2302582
100233176
Dog
GON7, KEOPS complex subunit
VGNC:41349
612321
Horse
GON7, KEOPS complex subunit
VGNC:18462
100053408
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GON7, KEOPS complex subunit
Mouse
Rat
Dog
GON7, KEOPS complex subunit
Horse
GON7, KEOPS complex subunit
Publication Statistics
PubMed Score 3.85
PubMed score by year
PubTator Score 1.44
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title