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Tbio
GON4L
GON-4-like protein

Protein Summary
Description
Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271883
  • ENSP00000271883
  • ENSG00000116580
  • ENST00000361040
  • ENSP00000354322
  • ENST00000368331
  • ENSP00000357315
  • ENST00000437809
  • ENSP00000396117
  • ENST00000615926
  • ENSP00000483100

Symbol
  • GON4
  • KIAA1606
  • GON4
  • YARP
  • GON-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
virus perturbation
0.68
kinase perturbation
0.66
tissue sample
0.64
cell line
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.7   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.7   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
CRAMP1
Tdark
Novelty:  0.26519971
p_int:  0.999999952
p_ni:  4.8e-8
Score:  0.854
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999999856
p_ni:  1.44e-7
Data Source:  BioPlex
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999999825
p_ni:  1.75e-7
Data Source:  BioPlex
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.989015419
p_ni:  0.010984581
Data Source:  BioPlex
ASB3
Tbio
Novelty:  0.15921018
p_int:  0.981282341
p_ni:  0.017213309
p_wrong:  0.00150435
Score:  0.169
Data Source:  BioPlex,STRINGDB
ASH1L
Tbio
Family:  Epigenetic
Novelty:  0.02897328
Score:  0.905
Data Source:  STRINGDB
YY1
Tbio
Family:  TF
Novelty:  0.00120891
Score:  0.682
Data Source:  STRINGDB
GOLPH3L
Tbio
Novelty:  0.30373124
Score:  0.627
Data Source:  STRINGDB
ACAD9
Tbio
Family:  Enzyme
Novelty:  0.03238308
Score:  0.611
Data Source:  STRINGDB
ASPHD1
Tdark
Family:  Enzyme
Novelty:  0.97195692
Score:  0.569
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
1
1
1
74.8
serum gamma-glutamyl transferase measurement
1
3
3
70
sex hormone-binding globulin measurement
2
1
2
61
appendicular lean mass
1
3
3
54.3
birth weight
1
1
1
51.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
1
74.8
serum gamma-glutamyl transferase measurement
3
70
sex hormone-binding globulin measurement
2
61
appendicular lean mass
3
54.3
birth weight
1
51.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gon-4 like
VGNC:8337
457373
Macaque
gon-4 like
719341
Mouse
MGI:1917579
76022
Rat
RGD:1564691
499653
Dog
gon-4 like
490422
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gon-4 like
Macaque
gon-4 like
Mouse
Rat
Dog
gon-4 like
Publication Statistics
PubMed Score 39.70
PubMed score by year
PubTator Score 7.54
PubTator score by year
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Related Publications
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PMID
Year
Title