Tbio GON4L GON-4-like protein

Protein Summary

Description

Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.

Uniprot Accession IDs

• Q3T8J9
• B7ZBL4
• Q14C93
• Q3T8J8
• Q5VYZ5
• Q5W0D5
• Q6AWA6
• Q6P1Q6
• Q7Z3L3
• Q8IY79
• Q9BQI1
• Q9HCG6

Gene Name

• GON4L

Ensembl ID

• ENST00000271883
• ENSP00000271883
• ENSG00000116580
• ENST00000361040
• ENSP00000354322
• ENST00000368331
• ENSP00000357315
• ENST00000437809
• ENSP00000396117
• ENST00000615926
• ENSP00000483100

Symbol

• GON4
• KIAA1606
• GON4
• YARP
• GON-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
virus perturbation	0.68
kinase perturbation	0.66
tissue sample	0.64
cell line	0.6

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Gon-4-like Protein

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Gon-4-like Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.13   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 13   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.13   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0