Protein Summary
Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.
- ENST00000271883
- ENSP00000271883
- ENSG00000116580
- ENST00000361040
- ENSP00000354322
- ENST00000368331
- ENSP00000357315
- ENST00000437809
- ENSP00000396117
- ENST00000615926
- ENSP00000483100
- GON4
- KIAA1606
- GON4
- YARP
- GON-4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.95 | ||
virus perturbation | 0.68 | ||
kinase perturbation | 0.66 | ||
tissue sample | 0.64 | ||
cell line | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.7 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 13 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.7 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 13 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (32)
CRAMP1
Novelty: 0.26519971
p_int: 0.999999952
p_ni: 4.8e-8
Score: 0.854
Data Source: BioPlex,STRINGDB
PNKD
Family: Enzyme
Novelty: 0.02456078
p_int: 0.989015419
p_ni: 0.010984581
Data Source: BioPlex
ASB3
Novelty: 0.15921018
p_int: 0.981282341
p_ni: 0.017213309
p_wrong: 0.00150435
Score: 0.169
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (3)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence Model (ISM) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
blood urea nitrogen measurement | 1 | 1 | 1 | 74.8 | |||||
serum gamma-glutamyl transferase measurement | 1 | 3 | 3 | 70 | |||||
sex hormone-binding globulin measurement | 2 | 1 | 2 | 61 | |||||
appendicular lean mass | 1 | 3 | 3 | 54.3 | |||||
birth weight | 1 | 1 | 1 | 51.7 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
blood urea nitrogen measurement | 1 | 74.8 | |||||
serum gamma-glutamyl transferase measurement | 3 | 70 | |||||
sex hormone-binding globulin measurement | 2 | 61 | |||||
appendicular lean mass | 3 | 54.3 | |||||
birth weight | 1 | 51.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | gon-4 like | VGNC:8337 | 457373 | |||||
Macaque | gon-4 like | 719341 | ||||||
Mouse | MGI:1917579 | 76022 | ||||||
Rat | RGD:1564691 | 499653 | ||||||
Dog | gon-4 like | 490422 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | gon-4 like | |||||
Macaque | gon-4 like | |||||
Mouse | ||||||
Rat | ||||||
Dog | gon-4 like | |||||
Publication Statistics
PubMed Score 39.70
PubMed score by year
PubTator Score 7.54
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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