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Tbio
GOLPH3
Golgi phosphoprotein 3

Protein Summary
Description
Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265070
  • ENSP00000265070
  • ENSG00000113384

Symbol
  • GPP34
  • GOPP1
  • GPP34
  • MIDAS
  • Vps74
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.86
interacting protein
0.86
transcription factor binding site profile
0.86
disease perturbation
0.83
tissue sample
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4722.8   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4722.8   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (230)
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.999991773
p_ni:  0.000008227
Data Source:  BioPlex
SSBP1
Tbio
Novelty:  0.01105839
p_int:  0.999755028
p_ni:  0.000244922
p_wrong:  5.1e-8
Data Source:  BioPlex
RASSF8
Tbio
Novelty:  0.09245647
p_int:  0.999671046
p_ni:  0.000328374
p_wrong:  5.8e-7
Data Source:  BioPlex
IMPAD1
Tbio
Family:  Enzyme
Novelty:  0.08211251
p_int:  0.998839414
p_ni:  0.001146921
p_wrong:  0.000013666
Data Source:  BioPlex
RCC1L
Tbio
Novelty:  0.03545003
p_int:  0.99846645
p_ni:  0.00153355
Score:  0.53
Data Source:  BioPlex,STRINGDB
ST3GAL1
Tchem
Family:  Enzyme
Novelty:  0.01236776
p_int:  0.997501922
p_ni:  0.002495983
p_wrong:  0.000002094
Score:  0.251
Data Source:  BioPlex,STRINGDB
AMIGO3
Tdark
Novelty:  7.6744186
p_int:  0.996563632
p_ni:  0.003436326
p_wrong:  4.1e-8
Data Source:  BioPlex
GPRC5C
Tbio
Family:  GPCR
Novelty:  0.16942353
p_int:  0.995890483
p_ni:  0.004108252
p_wrong:  0.000001265
Data Source:  BioPlex
GMPPA
Tbio
Family:  Enzyme
Novelty:  0.14050797
p_int:  0.995757653
p_ni:  0.004242347
Score:  0.865
Data Source:  BioPlex,STRINGDB
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.995045935
p_ni:  0.004954035
p_wrong:  3e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
40.7
reticulocyte count
1
1
1
33.1
monocyte count
1
1
1
10.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
40.7
reticulocyte count
1
33.1
monocyte count
1
10.4
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgi phosphoprotein 3
VGNC:6929
461946
Macaque
golgi phosphoprotein 3
700428
Mouse
MGI:1913879
66629
Rat
RGD:621226
78961
Dog
golgi phosphoprotein 3
VGNC:49691
489241
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgi phosphoprotein 3
Macaque
golgi phosphoprotein 3
Mouse
Rat
Dog
golgi phosphoprotein 3
Publication Statistics
PubMed Score 4722.80
PubMed score by year
PubTator Score 529.27
PubTator score by year
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Related Publications
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PMID
Year
Title