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Tbio
GOLIM4
Golgi integral membrane protein 4

Protein Summary
Description
Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reticulum and assist in the transport of protein cargo through the Golgi apparatus. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000470487
  • ENSP00000417354
  • ENSG00000173905

Symbol
  • GIMPC
  • GOLPH4
  • GPP130
  • P138
  • GIMPC
  • GOLPH4
  • GPP130
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
interacting protein
0.85
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83
cellular component
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.78   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.78   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.999972293
p_ni:  0.000027706
p_wrong:  1e-9
Data Source:  BioPlex
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.999964397
p_ni:  0.000035594
p_wrong:  9e-9
Data Source:  BioPlex
B3GAT3
Tbio
Family:  Enzyme
Novelty:  0.0289834
p_int:  0.999943938
p_ni:  0.000056032
p_wrong:  3e-8
Score:  0.546
Data Source:  BioPlex,STRINGDB
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.999924966
p_ni:  0.000075033
p_wrong:  1e-9
Data Source:  BioPlex
PRTN3
Tchem
Family:  Enzyme
Novelty:  0.00022728
p_int:  0.999747494
p_ni:  0.000252505
p_wrong:  1e-9
Data Source:  BioPlex
DCAF12
Tbio
Novelty:  0.15472702
p_int:  0.999689603
p_ni:  0.000310391
p_wrong:  6e-9
Data Source:  BioPlex
PTPRU
Tbio
Family:  Enzyme
Novelty:  0.0090218
p_int:  0.999180459
p_ni:  0.00081954
p_wrong:  1e-9
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.998896029
p_ni:  0.001101825
p_wrong:  0.000002145
Data Source:  BioPlex
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.998671663
p_ni:  0.001328337
Data Source:  BioPlex
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.997006949
p_ni:  0.002993051
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
43.9
hematocrit
1
1
1
8.5
proliferative diabetic retinopathy
1
1
0
3.1
1.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
43.9
hematocrit
1
8.5
proliferative diabetic retinopathy
0
3.1
1.3
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgi integral membrane protein 4
VGNC:1830
460835
Macaque
golgi integral membrane protein 4
713937
Mouse
MGI:1920374
73124
Rat
RGD:1310948
310526
Dog
golgi integral membrane protein 4
VGNC:41344
478685
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgi integral membrane protein 4
Macaque
golgi integral membrane protein 4
Mouse
Rat
Dog
golgi integral membrane protein 4
Publication Statistics
PubMed Score 53.78
PubMed score by year
PubTator Score 22.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title