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Tbio
GOLGA5
Golgin subfamily A member 5

Protein Summary
Description
Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000163416
  • ENSP00000163416
  • ENSG00000066455

Symbol
  • RETII
  • RFG5
  • RFG5
  • GOLIM5
  • ret-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
histone modification site profile
0.83
cell type or tissue
0.8
kinase perturbation
0.71
transcription factor binding site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.61   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.61   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
VSTM1
Tbio
Novelty:  0.08630646
p_int:  0.999902626
p_ni:  0.000097374
Data Source:  BioPlex
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.999362029
p_ni:  0.000637971
Data Source:  BioPlex
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.9993318
p_ni:  0.0006682
Score:  0.199
Data Source:  BioPlex,STRINGDB
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
p_int:  0.99707703
p_ni:  0.00292297
Data Source:  BioPlex
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.996588531
p_ni:  0.003411469
Data Source:  BioPlex
SLC6A15
Tchem
Family:  Transporter
Novelty:  0.04011524
p_int:  0.994074333
p_ni:  0.005925667
Data Source:  BioPlex
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
p_int:  0.992920709
p_ni:  0.007079291
Data Source:  BioPlex
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.991963618
p_ni:  0.008036382
Data Source:  BioPlex
CD27
Tbio
Novelty:  0.00090508
p_int:  0.991098275
p_ni:  0.008901725
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.990890261
p_ni:  0.009109739
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
2
4
82.9
appendicular lean mass
1
1
1
60
body height
1
1
1
57.8
serum metabolite measurement
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
4
82.9
appendicular lean mass
1
60
body height
1
57.8
serum metabolite measurement
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgin A5
VGNC:3415
453119
Macaque
golgin A5
698378
Mouse
MGI:1351475
27277
Rat
RGD:1308163
299258
Dog
golgin A5
VGNC:41341
480233
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgin A5
Macaque
golgin A5
Mouse
Rat
Dog
golgin A5
Publication Statistics
PubMed Score 26.61
PubMed score by year
PubTator Score 12.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title