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Tclin
GNRHR
Gonadotropin-releasing hormone receptor

Protein Summary
Description
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226413
  • ENSP00000226413
  • ENSG00000109163
  • ENST00000420975
  • ENSP00000397561

Symbol
  • GRHR
  • HH7
  • GRHR
  • LRHR
  • LHRHR
  • GNRHR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.97
biological term
0.82
cell type or tissue
0.7
trait
0.61
drug
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.71   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.71   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 986
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13