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Tbio
GNPTAB
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

Protein Summary
Description
Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene hav ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299314
  • ENSP00000299314
  • ENSG00000111670
  • ENST00000549940
  • ENSP00000449150

Symbol
  • GNPTA
  • KIAA1208
  • ICD
  • GNPTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
transcription factor perturbation
0.84
disease perturbation
0.74
phenotype
0.73
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 496.27   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 496.27   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
PICK1
Tbio
Novelty:  0.0058265
p_int:  0.9997978
p_ni:  0.000202194
p_wrong:  7e-9
Score:  0.245
Data Source:  BioPlex,STRINGDB
IGSF6
Tbio
Novelty:  0.05015035
p_int:  0.999632964
p_ni:  0.000367035
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
ZPLD1
Tbio
Novelty:  0.19418088
p_int:  0.998720372
p_ni:  0.001279627
Score:  0.552
Data Source:  BioPlex,STRINGDB
B3GALT2
Tbio
Family:  Enzyme
Novelty:  0.23873109
p_int:  0.99868125
p_ni:  0.001318749
p_wrong:  1e-9
Score:  0.232
Data Source:  BioPlex,STRINGDB
SGCZ
Tbio
Novelty:  0.08511312
p_int:  0.99699528
p_ni:  0.00300472
Score:  0.157
Data Source:  BioPlex,STRINGDB
RETREG3
Tdark
Novelty:  0.99215801
p_int:  0.99259571
p_ni:  0.00740429
Data Source:  BioPlex
RASSF7
Tbio
Novelty:  0.08011259
p_int:  0.982014529
p_ni:  0.017985471
Score:  0.543
Data Source:  BioPlex,STRINGDB
FAM3B
Tbio
Novelty:  0.00844967
p_int:  0.9397296
p_ni:  0.060270369
p_wrong:  3.1e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
PXYLP1
Tbio
Family:  Enzyme
Novelty:  0.04672634
p_int:  0.920774454
p_ni:  0.0792255
p_wrong:  4.7e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
GNPTG
Tbio
Family:  Enzyme
Novelty:  0.03345886
p_int:  0.818540755
p_ni:  0.18145904
p_wrong:  2.05e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
18
8
22
91.8
vitamin C measurement
1
1
1
89
aspartate measurement
1
1
0
11.9
82.1
cathepsin D measurement
1
1
1
76.2
1
1
0
1.2
68.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
22
91.8
vitamin C measurement
1
89
aspartate measurement
0
11.9
82.1
cathepsin D measurement
1
76.2
0
1.2
68.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
VGNC:8414
452176
Macaque
N-acetylglucosamine-1-phosphate transferase alpha and beta subunits
697307
Mouse
MGI:3643902
432486
Rat
RGD:1564821
362865
Dog
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
VGNC:41334
475443
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
Macaque
N-acetylglucosamine-1-phosphate transferase alpha and beta subunits
Mouse
Rat
Dog
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
Publication Statistics
PubMed Score 496.27
PubMed score by year
PubTator Score 109.29
PubTator score by year
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Related Publications
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PMID
Year
Title