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Tbio
GNPNAT1
Glucosamine 6-phosphate N-acetyltransferase

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216410
  • ENSP00000216410
  • ENSG00000100522
  • ENST00000650397
  • ENSP00000496934

Symbol
  • GNA1
  • GNA1
  • GNPNAT
  • Gpnat1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor perturbation
0.88
histone modification site profile
0.83
transcription factor binding site profile
0.71
microRNA
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.71   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.71   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
MAPT
Tclin
Novelty:  0.00013232
p_int:  0.963603138
p_ni:  0.007010816
p_wrong:  0.029386046
Score:  0.188
Data Source:  BioPlex,STRINGDB
FABP1
Tchem
Novelty:  0.00192691
p_int:  0.945013934
p_ni:  0.016225777
p_wrong:  0.038760289
Score:  0.42
Data Source:  BioPlex,STRINGDB
RDH5
Tbio
Family:  Enzyme
Novelty:  0.0111079
p_int:  0.89637189
p_ni:  0.090899188
p_wrong:  0.012728921
Score:  0.403
Data Source:  BioPlex,STRINGDB
HSD17B6
Tbio
Family:  Enzyme
Novelty:  0.01428594
p_int:  0.89637189
p_ni:  0.090899188
p_wrong:  0.012728921
Score:  0.188
Data Source:  BioPlex,STRINGDB
NFKBIA
Tchem
Novelty:  0.00022873
p_int:  0.89637189
p_ni:  0.090899188
p_wrong:  0.012728921
Score:  0.15
Data Source:  BioPlex,STRINGDB
MRPL4
Tdark
Novelty:  0.27290276
p_int:  0.89637189
p_ni:  0.090899188
p_wrong:  0.012728921
Data Source:  BioPlex
OR5F1
Tdark
Family:  oGPCR
Novelty:  13
p_int:  0.787991045
p_ni:  0.00238879
p_wrong:  0.209620164
Score:  0.23
Data Source:  BioPlex,STRINGDB
PGM3
Tbio
Family:  Enzyme
Novelty:  0.00515842
Score:  0.988
Data Source:  STRINGDB
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
Score:  0.985
Data Source:  STRINGDB
GFPT1
Tchem
Family:  Enzyme
Novelty:  0.00358283
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of UDP-N-acetyl-glucosamine
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of UDP-N-acetyl-glucosamine
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
3
66.2
1
1
0
1.1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
66.2
0
1.1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucosamine-phosphate N-acetyltransferase 1
VGNC:3416
467460
Macaque
glucosamine-phosphate N-acetyltransferase 1
693834
Mouse
MGI:1858963
54342
Rat
RGD:1563144
498486
Dog
glucosamine-phosphate N-acetyltransferase 1
VGNC:41333
480325
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucosamine-phosphate N-acetyltransferase 1
Macaque
glucosamine-phosphate N-acetyltransferase 1
Mouse
Rat
Dog
glucosamine-phosphate N-acetyltransferase 1
Publication Statistics
PubMed Score 63.71
PubMed score by year
PubTator Score 13.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title