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Tchem
GNPAT
Dihydroxyacetone phosphate acyltransferase

Protein Summary
Description
This gene encodes an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids. Mutations in this gene are associated with rhizomelic chondrodysplasia punctata. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366647
  • ENSP00000355607
  • ENSG00000116906

Symbol
  • DAPAT
  • DHAPAT
  • DAPAT
  • RCDP2
  • DAP-AT
  • DHAPAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.93
co-expressed gene
0.87
histone modification site profile
0.84
interacting protein
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.08   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.08   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0